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Merck
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주요 문서

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I2778

Sigma-Aldrich

IL-1α human

≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

동의어(들):

IL-1α, hIL-1α., Interleukin-1α human, Lymphocyte activating factor

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About This Item

MDL number:
MFCD00164814
UNSPSC 코드:
12352202
NACRES:
NA.77

제품명

Interleukin-1α human, IL-1α, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

생물학적 소스

human

Quality Level

100

재조합

expressed in E. coli

분석

≥98% (SDS-PAGE and HPLC)

양식

lyophilized powder

품질

endotoxin tested

분자량

~17 kDa

포장

pkg of 2 and 10 μg

기술

cell culture | mammalian: suitable

UniProt 수납 번호

P01583

저장 온도

−20°C

유전자 정보

human ... IL1A(3552)

관련 카테고리

일반 설명

Interleukin-1α (IL-1α) is a cytokine that belongs to the interleukin-1 (IL-1) family. It is located intracellularly in hematopoietic and non-hematopoietic cells. IL-1α gene is located on the human chromosome at 2q14.1.

애플리케이션

Interleukin-1α (IL-1α) has been used:
  • to study its effects on human colorectal adenocarcinoma cells
  • to stimulate primary human fetal retinal pigment epithelium (hfRPE) cells
  • to pre-stimulate human THP-1 monocytes

생화학적/생리학적 작용

Interleukin-1α (IL-1α) plays a crucial role in inflammation during cell necrosis. It also regulates the recruitment of interleukin-1β (IL-1β), neutrophils, chemokines, and other cytokines at the site of injury. IL-1α exhibits a dual function of binding to its cell surface receptor as well as chromatin.

물리적 형태

Lyophilized from 0.2 μm filtered 10 mM sodium phosphate , pH 8.0, plus 50 mm NaCl and 50 μg bovine serum albumin (BSA) per μg cytokine.

분석 메모

The proliferative activity of human IL-1α is tested in culture using the murine cell line D10S.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H315,H319,H335

예방조치 성명서

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

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시험 성적서(COA)

Lot/Batch Number
SLCL7384
SLCL3232
SLCK6389
SLCH0210
MKCL9262

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문서 라이브러리 방문

Nelson C Di Paolo et al.
Nature immunology, 17(8), 906-913 (2016-07-21)
Inflammation occurs after disruption of tissue homeostasis by cell stress, injury or infection and ultimately involves the recruitment and retention of cells of hematopoietic origin, which arrive at the affected sites to resolve damage and initiate repair. Interleukin 1α (IL-1α)
Ivo C J H Post et al.
Xenotransplantation, 20(1), 18-26 (2013-01-26)
Endothelial damage is a critical step in the development of (xeno) transplantation-related and cardiovascular pathology. In humans, the amount of circulating endothelial cells (CEC) correlates to disease intensity and functions as a valuable damage marker. While (xeno) transplantation and cardiovascular
Symons, J.A., et al. et al.
Lymphokines and Interferons, A Practical Approach, 272-272 (1987)
Cassandra Kosmidou et al.
Scientific reports, 8(1), 461-461 (2018-01-13)
Contradictory data have been presented regarding the implication of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome in age-related macular degeneration (AMD), the leading cause of vision loss in the Western world. Recognizing that antibody specificity may explain
Hans R Lüttichau
The Journal of biological chemistry, 285(12), 9137-9146 (2010-01-02)
Large DNA viruses, such as herpesvirus and poxvirus, encode proteins that target and exploit the chemokine system of their host. UL146 and UL147 in the cytomegalovirus (CMV) genome encode the two CXC chemokines vCXCL1 and vCXCL2. In this study, vCXCL1
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문서

Interleukin Family (IL)

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages and monocytes and plays a key role in inflammatory and immune responses and may induce anti-tumor immunity.

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