H7779

Retinoic acid p-hydroxyanilide

≥95%

• 동의어(들): 4-HPR, Fenretinide, N-(4-Hydroxyphenyl)retinamide
• 실험식(Hill 표기법): C₂₆H₃₃NO₂
• CAS Number: 65646-68-6
• Molecular Weight: 391.55
• MDL number: MFCD00792674
• UNSPSC 코드: 12352106
• PubChem Substance ID: 24278472
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 분석: ≥95%
• 양식: powder
• 색상: yellow to yellow-orange
• 저장 온도: −20°C
• SMILES string: CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(=O)Nc2ccc(O)cc2)C(C)(C)CCC1
• InChI: 1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+
• InChI key: AKJHMTWEGVYYSE-FXILSDISSA-N

설명

일반 설명

Retinoic acid p-hydroxyanilide is a synthetic analog of retinoid.

애플리케이션

Retinoic acid p-hydroxyanilide has been used:

• as a synthetic retinoid to induce apoptosis in SEB-1 sebocytes
• as a medium supplement for C2C12 myoblasts to test its effect on ceramide formation
• to test in cytotoxicity in T-cell acute lymphoblastic leukemia (T-ALL)

생화학적/생리학적 작용

Retinoic acid p-hydroxyanilide, also called fenretinide, increases reactive oxygen species, activates caspases and induces apoptosis. It also inhibits dihydroceramide desaturase, leading to a decrease in ceramide biosynthesis. Fenretinide may elicit anticancer activity in cultured human breast cancer cells. It acts as an insulin antagonist and may be useful in treating insulin resistance. Fenretinide or 4-HPR has chemotherapeutic potential and is cytotoxic to retinoic acid-resistant cancers.

Vitamin A acid analogue with antiproliferative activity; induces apoptosis in malignant hemopoietic cell lines.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302 + H312 + H332,H315,H319,H335,H360
• 예방조치 성명서: P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges