추천 제품
생물학적 소스
human
Quality Level
재조합
expressed in HEK 293 cells
분석
>95% (SDS-PAGE)
양식
lyophilized powder
효능
≤0.6 ng/mL EC50
품질
endotoxin tested
분자량
dimer 14-19 kDa (glycosylated)
포장
pkg of 1 mg
pkg of 10 μg
pkg of 100 μg
제조업체/상표
HumanZyme
기술
cell culture | mammalian: suitable
불순물
<1 EU/μg
UniProt 수납 번호
저장 온도
−20°C
유전자 정보
human ... IL4(3565)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
Interleukin-4 (IL-4) is a pleiotropic cytokine and a complex glycoprotein mapped to human chromosome 5q31.1. It is produced by mast cells, basophils and a subset of activated T cells.
생화학적/생리학적 작용
Interleukin-4 (IL-4) interacts with interleukin 13 and is an interleukin-4 receptor ligand. It regulates IgE and IgG1 production by B cells. IL-4 favors glial and neuronal differentiation and regulates differentiation of naive cluster of differentiation CD4+ T cells to the T helper type 2 (TH2) cells. Polymorphism in the IL-4 gene is implicated in immune and inflammatory disorders. In cerebral infarction, IL-4 levels are elevated.
물리적 형태
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
제조 메모
HumanKine Interleukin-4 (IL-4), expressed in human HEK 293 cells, is a glycosylated monomer with an apparent molecular mass of 14-19 kDa due to glycosylation, which is absent when this cytokine is expressed in E. coli. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
분석 메모
The activity is determined by the dose-dependent simulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).
법적 정보
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
이미 열람한 고객
IL-4: role in disease and regulation of production.
P Choi et al.
Clinical and experimental immunology, 113(3), 317-319 (1998-09-16)
Muscle as an endocrine organ
Muscle and Exercise Physiology, 13(4) (2019)
Interleukin 4 Receptor
Muscle and Exercise Physiology, 13(4) (1998)
Neurogenesis, Inflammation, and Mental Health
Inflammation and Immunity in Depression, 13(4) (2018)
Cody J Warren et al.
Cell, 185(21), 3980-3991 (2022-10-02)
Simian arteriviruses are endemic in some African primates and can cause fatal hemorrhagic fevers when they cross into primate hosts of new species. We find that CD163 acts as an intracellular receptor for simian hemorrhagic fever virus (SHFV; a simian
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