H4413

Hydroxyfasudil hydrochloride hydrate

≥98% (HPLC), solid

• 동의어(들): 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate
• 실험식(Hill 표기법): C₁₄H₁₇N₃O₃S · HCl · xH₂O
• CAS Number: 155558-32-0
• Molecular Weight: 343.83 (anhydrous basis)
• MDL number: MFCD06411567
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24724499
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 구성: The two peaks show the equilibrim between the two tautomers
• 색상: white
• solubility: H₂O: >5 mg/mL
• 저장 온도: 2-8°C
• SMILES string: Cl[H].Oc1nccc2c(cccc12)S(=O)(=O)N3CCCNCC3
• InChI: 1S/C14H17N3O3S.ClH/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17;/h1,3-5,7,15H,2,6,8-10H2,(H,16,18);1H
• InChI key: XWWFOUVDVJGNNG-UHFFFAOYSA-N

설명

애플리케이션

Hydroxyfasudil hydrochloride hydrate has been used as a ROCK inhibitor to study the role of different signaling pathways in the chemokines CCL19 and CCL21, the CCR7 ligands mediated effects on migratory and prosurvival, in CLL cells.

생화학적/생리학적 작용

Hydroxyfasudil possessantispastic action. It is an active metabolite of fasudil. Hydroxyfasudil might enhance the dynamics of blood flow and prevent damage caused by neutrophils.

Rho-kinase inhibitor.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves