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Merck
모든 사진(1)

주요 문서

GW22348F

Sigma-Aldrich

Anti-LXN antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

chicken

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

양식

buffered aqueous solution

종 반응성

human, mouse, rat

제조업체/상표

Genway 15-288-22348F

기술

indirect ELISA: suitable
western blot: suitable

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... LXN(56925)

일반 설명

LXN (latexin) is the human homologue of endogenous inhibitor of carboxypeptidase A found in rat. It was initially recognized as a neural marker in developing mammalian brain, of the lateral neocortex. This protein is composed of 222 amino acids. An α-helix links two subdomains that comprise the protein. It has high structural homology to TIG1 (tazarotene-induced gene 1).

면역원

Immunogen Sequence: GI # 9910396, sequence 1-222
Recombinant latexin protein

애플리케이션

Anti-LXN antibody produced in chicken is suitable for indirect ELISA and western blotting.

생화학적/생리학적 작용

Latexin (LXN) is a negative regulator of hematopoietic stem cell and may exert its tumor-suppressive function by altering the stem cell-like properties of melanoma cells. Its expression is reduced in human gastric cancers compared with their normal control tissues. LXN expression may have involvement in tumor suppression. It may have clinical efficacy in the treatment of malignancies.

물리적 형태

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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문서 라이브러리 방문

Yi Liu et al.
PloS one, 7(9), e44979-e44979 (2012-10-03)
Latexin is a negative regulator of hematopoietic stem cell number in mice. Its dysregulated expression in other tumors led us to hypothesize that latexin may have tumor suppressor properties in hematological malignancies. We found that latexin was down-regulated in a
Yong Li et al.
BMC cancer, 11, 121-121 (2011-04-07)
Latexin, also known as endogenous carboxypeptidase inhibitor (CPI), has been found to inhibit mouse stem cell populations and lymphoma cell proliferation, demonstrating its potential role as a tumor suppressor. Our previous study also suggested a correlation between latexin expression and

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