추천 제품
생물학적 소스
chicken
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
종 반응성
rat, mouse, human
제조업체/상표
Genway 15-288-21470
기술
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... PPFIA1(8500)
면역원
Immunogen Sequence: GI # 4505983, sequence 310-360
Recombinant PTPRF interacting protein α 1 isoform b
애플리케이션
Anti-PPFIA1 (ab1) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
생화학적/생리학적 작용
Liprin-α-1 is a cytoplasmic 160kDa phosphoserine protein encoded by the PPFIA1 gene in humans. It encodes liprin α, a protein involved in cell adhesion, integrin expression and cell-matrix interactions. PPFIA1 may act as a potential functional candidate for acute lung injury risk gene for future research. It is frequently co-amplified with the Cyclin D1 gene in oral carcinomas and may present a biomarker as well as a novel target for specific gene therapy. Liprin′s function is to localize LAR family tyrosine phosphatases at specific sites on the plasma membrane. It may help in regulating their interaction with the extracellular environment and their associations with substrates. PPFIA1 may regulate the disassembly of focal adhesions and help to orchestrate cell-matrix interactions.
물리적 형태
Solution in phosphate buffered saline containing 0.02% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
가장 최신 버전 중 하나를 선택하세요:
Marco Blessmann et al.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 41(8), 845-849 (2013-03-05)
Analyzing chromosomal amplifications delivers valuable information for identification of oncogenes. For carcinomas of the oral cavity only few genes have been identified in amplified regions. The aim of this study was to search genes in amplified regions as possible biomarkers
Jason D Christie et al.
PloS one, 7(1), e28268-e28268 (2012-02-02)
Acute Lung Injury (ALI) is a syndrome with high associated mortality characterized by severe hypoxemia and pulmonary infiltrates in patients with critical illness. We conducted the first investigation to use the genome wide association (GWA) approach to identify putative risk
C Serra-Pagès et al.
The EMBO journal, 14(12), 2827-2838 (1995-06-15)
Focal adhesions are sites of cell-extracellular matrix interactions that function in anchoring stress fibers to the plasma membrane and in adhesion-mediated signal transduction. Both focal adhesion structure and signaling ability involve protein tyrosine phosphorylation. LAR is a broadly expressed transmembrane
C Serra-Pagès et al.
The Journal of biological chemistry, 273(25), 15611-15620 (1998-06-23)
LAR family transmembrane protein-tyrosine phosphatases function in axon guidance and mammary gland development. In cultured cells, LAR binds to the intracellular, coiled coil LAR-interacting protein at discrete ends of focal adhesions, implicating these proteins in the regulation of cell-matrix interactions.
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