F6777
Flecainide acetate salt
≥98% (TLC), powder, sodium channel blocker
동의어(들):
N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate salt
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모든 사진(3)
About This Item
실험식(Hill 표기법):
C17H20F6N2O3 · C2H4O2
CAS Number:
Molecular Weight:
474.39
EC Number:
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
제품명
Flecainide acetate salt,
Quality Level
주관자
Medicis
저장 온도
2-8°C
SMILES string
CC(O)=O.FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC2CCCCN2
InChI
1S/C17H20F6N2O3.C2H4O2/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11;1-2(3)4/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26);1H3,(H,3,4)
InChI key
RKXNZRPQSOPPRN-UHFFFAOYSA-N
유전자 정보
human ... SCN5A(6331)
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관련 카테고리
생화학적/생리학적 작용
Class IC antiarrhythmic agent; sodium channel blocker
특징 및 장점
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Medicis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
이미 열람한 고객
Drug therapy. Flecainide.
D M Roden et al.
The New England journal of medicine, 315(1), 36-41 (1986-07-03)
P Somani
Clinical pharmacology and therapeutics, 27(4), 464-470 (1980-04-01)
A new class I antiarrhythmic, flecainide, was investigated in 10 patients to assess short-term efficacy and safety. All patients were hospitalized for 3 days; no antiarrhythmics were given on days 1 and 3. On day 2 flecainide 1 mg/kg was
The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome.
Naomasa Makita et al.
The Journal of clinical investigation, 118(6), 2219-2229 (2008-05-03)
Phenotypic overlap of type 3 long QT syndrome (LQT3) with Brugada syndrome (BrS) is observed in some carriers of mutations in the Na channel SCN5A. While this overlap is important for patient management, the clinical features, prevalence, and mechanisms underlying
Kosuke Doki et al.
Pharmacogenetics and genomics, 22(11), 777-783 (2012-09-04)
To investigate the association between age-related decline in flecainide clearance and CYP2D6 genotype, we conducted a population pharmacokinetic analysis of flecainide using routine therapeutic drug monitoring data. Population pharmacokinetic analysis was performed on retrospective data from 163 genotyped patients treated
Nian Liu et al.
Trends in cardiovascular medicine, 22(2), 35-39 (2012-08-08)
Recent studies have shown that flecainide may be an effective therapy to prevent life-threatening arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. Several hypotheses have been advanced to explain the antiarrhythmic mechanism of flecainide, including Na(+) channel blockade and a
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