추천 제품
제품명
Fumagillin from Aspergillus fumigatus, ≥90%, powder
생물학적 소스
Aspergillus sp. (Aspergillus fumigatus)
Quality Level
분석
≥90%
양식
powder
색상
white
mp
197-198 °C
solubility
ethanol: 1 mg/mL
항생제 활성 스펙트럼
fungi
동작 모드
DNA synthesis | interferes
저장 온도
−20°C
SMILES string
COC1C(CCC2(CO2)C1C3(C)OC3C\C=C(\C)C)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O
InChI
1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+
InChI key
NGGMYCMLYOUNGM-HCNIIHBUSA-N
일반 설명
Fumagillin is a metabolic product of fungi. It is originally isolated from Aspergillus fumigatus.
애플리케이션
Fumagillin from Aspergillus fumigatus has been used:
- in chick chorioallantoic membrane (CAM) assay to study the changes in protein expression in response to anti-angiogenic agent
- to study its effects on the mortality of caged Nosema ceranae-infected honey bees- write in this way
- as a positive control in in vitro and ex vivo studies
생화학적/생리학적 작용
Fumagillin is known to be effective against microsporidian fungal infections.
Methionine aminopeptidase-2 (MetAP-2) inhibitor; inhibits endothelial cell proliferation and angiogenesis.
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
Fumagillin: an overview of recent scientific advances and their significance for apiculture
van den Heever JP, et al.
Journal of Agricultural and Food Chemistry, 62(13), 2728-2737 (2014)
The effect of dicyclohexylamine and fumagillin on Nosema ceranae-infected honey bee (Apis mellifera) mortality in cage trial assays
Van den Heever JP, et al.
Apidologie, 47(5), 663-670 (2016)
A novel technique for quantifying changes in vascular density, endothelial cell proliferation and protein expression in response to modulators of angiogenesis using the chick chorioallantoic membrane (CAM) assay
Miller WJ, et al.
Journal of Translational Medicine, 2(1), 4-4 (2004)
Fred R Musser et al.
Journal of invertebrate pathology, 111(2), 101-105 (2012-07-24)
A consistent supply of healthy tarnished plant bug, Lygus lineolaris (Palisot de Beauvois) (Hemiptera: Miridae), is necessary for the development of novel management strategies targeting this pest. After being in culture for several years, a substantial portion of a tarnished
Hsiao-Ching Lin et al.
Journal of the American Chemical Society, 135(12), 4616-4619 (2013-03-16)
Fumagillin 1 is a meroterpenoid from Aspergillus fumigatus that is known for its anti-angiogenic activity by binding to human methionine aminopeptidase 2. The genetic and molecular basis for biosynthesis of 1 had been an enigma despite the availability of the
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