추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
종 반응성
human
기술
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 3-16 μg/mL using human heart tissue
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−70°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... EDNRA(1909)
mouse ... Ednra(13617)
rat ... Ednra(24326)
면역원
synthetic peptide corresponding to the third extracellular domain of human endothelin A receptor, conjugated to KLH. The immunizing peptide has 100% homology with mouse
애플리케이션
Anti-Endothelin A Receptor antibody produced in rabbitis suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 3-16μg/mL using human heart tissue.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
생화학적/생리학적 작용
Endothelin A Receptor (ETA) is one of three endothelin receptors that mediates the effects of endothelin-1, a vasoconstrictor peptide. Located in the smooth muscle tissue of blood vessels, the interaction between endothelin and ETA plays a role in the regulation of blood pressure. Endothelin receptor type A (ETA, ETAR) is a human G protein-coupled receptor that mediates vasoconstriction of blood vessels. It is involved in tumor cell invasion, survival and metastasis. ETA mediates the promotion of ET-1 on colon cancer cell survival, invasion and MMP-2 expression by a PI3K-mediated mechanism. It plays a critical role in colon cancer metastasis.
물리적 형태
Solution in phosphate buffered saline containing 0.1% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
H Z Toklu et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 67(2), 205-216 (2016-05-27)
The objective of the study was to determine the effects of a high fat (HF) diet alone or with high fructose (HF/F) on functional and structural changes in the basilar arteries and cardiovascular health parameters in rats. Male Sprague Dawley
Gry Freja Skovsted et al.
Basic & clinical pharmacology & toxicology, 117(5), 297-305 (2015-04-22)
In ischaemic hearts, endothelin (ET) levels are increased, and vasoconstrictor responses to ET-1 are greatly enhanced. We previously reported that ETB receptors are up-regulated in the smooth muscle layer of coronary arteries after myocardial ischaemia-reperfusion and that the MEK-ERK1/2 signalling
Shaolin Nie et al.
Molecular carcinogenesis, 53 Suppl 1, E85-E91 (2013-07-03)
The endothelin (ET)-1/endothelin A receptor (ETAR) axis is reportedly involved in tumor cell invasion, survival, and metastasis. However, the role of ETAR in colon cancer metastasis and the underlying mechanisms have not been defined. In the present study, we assessed
Amanda J Leblanc et al.
Microcirculation (New York, N.Y. : 1994), 20(5), 365-376 (2012-12-04)
The risk for cardiovascular disease increases with advancing age; however, the chronological development of heart disease differs in males and females. The purpose of this study was to determine whether age-induced alterations in responses of coronary arterioles to the endogenous
Mirosław Banasik et al.
Human immunology, 75(8), 859-862 (2014-06-22)
Antibodies against donor's HLA antigens and B cell activity are recognized modulators of immune response to allograft. The role of both anti-HLA and non-HLA antibodies is understood in solid organ transplantation, but has not been addressed in composite tissue allografts.
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