D8040
(±)-trans-U-50488 methanesulfonate salt
동의어(들):
trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate salt, U-50488H
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모든 사진(3)
About This Item
실험식(Hill 표기법):
C19H26Cl2N2O · CH4O3S
Molecular Weight:
465.43
MDL number:
UNSPSC 코드:
12352106
PubChem Substance ID:
NACRES:
NA.77
추천 제품
양식
powder
Quality Level
solubility
H2O: 50 mg/mL
저장 온도
2-8°C
SMILES string
CS(O)(=O)=O.CN([C@@H]1CCCC[C@H]1N2CCCC2)C(=O)Cc3ccc(Cl)c(Cl)c3
InChI
1S/C19H26Cl2N2O.CH4O3S/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;1-5(2,3)4/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1H3,(H,2,3,4)/t17-,18-;/m1./s1
InChI key
OJPHNZCUXUUVKU-JAXOOIEVSA-N
유전자 정보
human ... OPRK1(4986)
애플리케이션
(±)-trans-U-50488 methanesulfonate salt has been used as a control agonist for κ-opioid receptor.
생화학적/생리학적 작용
Selective κ-opioid receptor agonist. (±)-trans-U-50488 methanesulfonate salt is known to induce diuresis. U-50488H is found to prevent morphine tolerance when administered along with it.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain
Basile AS, et al.
Journal of Pharmacology and Experimental Therapeutics, 321(3), 1208-1225 (2007)
X C Yu et al.
Journal of molecular and cellular cardiology, 31(10), 1809-1819 (1999-10-20)
During myocardial ischaemia the beta-adrenoceptor is activated, which contributes, at least partly, to cardiac arrhythmias via inducing [Ca2+]i oscillations. Since beta-adrenoceptor is negatively modulated by the kappa-opioid receptor in the heart, the present study attempted to determine if kappa-opioid receptor
Opioid receptor delta as a global modulator of skin differentiation and barrier function repair
Chajra H, et al.
International Journal of Cosmetic Science, 37(4), 386-394 (2015)
Pharmacology and Therapeutics in the New Millennium, 462-462 (2001)
Unique behavioural phenotypes of recombinant-inbred CXBK mice: partial deficiency of sensitivity to μ- and κ-agonists.
Ikeda, K., et al.
Journal of Neuroscience Research, 34, 149-155 (1999)
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