D7783

Pyrroloquinoline quinone

≥95.0% (HPLC)

• 동의어(들): 4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, Methoxatin, PQQ
• 실험식(Hill 표기법): C₁₄H₆N₂O₈
• CAS Number: 72909-34-3
• Molecular Weight: 330.21
• Beilstein: 3596812
• MDL number: MFCD00043125
• UNSPSC 코드: 12352106
• PubChem Substance ID: 24894162
• NACRES: NA.79

속성

• 생물학적 소스: synthetic
• Quality Level: 200
• 분석: ≥95.0% (HPLC)
• 양식: powder
• 기술: HPLC: suitable
• 색상: red to deep red
• 저장 온도: 2-8°C
• SMILES string: OC(=O)c1cc(C(O)=O)c-2c(n1)C(=O)C(=O)c3cc([nH]c-23)C(O)=O
• InChI: 1S/C14H6N2O8/c17-10-4-2-6(14(23)24)15-8(4)7-3(12(19)20)1-5(13(21)22)16-9(7)11(10)18/h1-2,15H,(H,19,20)(H,21,22)(H,23,24)
• InChI key: MMXZSJMASHPLLR-UHFFFAOYSA-N

설명

일반 설명

Novel o-quinone coenzyme found in bacterial dehydrogenases and oxidases.

Pyrroloquinoline Quinone (PQQ), also referred as methoxatin, is a water soluble orthoquinone molecule with redox-cycling ability.

애플리케이션

Pyrroloquinoline quinone has been used:

• as a component of nanocurcumin formulation (NCF), to study its therapeutic effect on ameliorate hypoxia-induced stress in hypertrophied cardiomyocytes
• as a standard in fluorescence analysis
• to test its efficiency in suppressing restrained oxidative stress and hepatic fibrogenesis in mouse models

생화학적/생리학적 작용

PQQ is present in nanomolar quantities in most foods and in most animal tissuse. It promotes growth, mitochondrial function, and development in vivo and stimulates cell proliferation and viability in culture. It is a potent antioxidant that scavenges superoxide and peroxinitrite. It is neuroprotectant against 6-hydroxydopamine-induced and hypoxia/ischemia-induced neurotoxicity. PQQ conjugates to α-synuclein in vitro, inhibiting the formation of amyloid fibrils.

Pyrroloquinoline Quinone (PQQ) plays a vital role in gluconic acid production and biosynthesis by microbes. It acts as an effective microbial growth stimulant and biological control determinant for plant pathogens. PQQ also acts as an anti-melanogenic agent and is used to treat disorders related to hyper pigmentation. It exhibits diverse role in metabolism and cell signaling pathways. PQQ is used as a potential therapeutic to treat liver fibrosis.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)