D5193

17-Dimethylaminoethylamino-17-demethoxygeldanamycin

• 동의어(들): 17-DMAG
• 실험식(Hill 표기법): C₃₂H₄₈N₄O₈
• Molecular Weight: 616.75
• UNSPSC 코드: 51102829
• NACRES: NA.85

속성

• 생물학적 소스: synthetic
• Quality Level: 100
• 양식: powder
• 색상: dark red-purple to black
• solubility: ethanol: ~10 mg/mL (lit.); DMSO: >25 mg/mL (lit.)
• 항생제 활성 스펙트럼: neoplastics
• 동작 모드: protein synthesis | interferes
• 저장 온도: −20°C

설명

일반 설명

Chemical structure: benzenoid

애플리케이션

17-DMAG has been used to block the NF-κB inflammatory cascade in the murine model. It a potential therapeutic agent for non-small-cell lung cancers (NSCLC).

생화학적/생리학적 작용

17-DMAG is a heat shock protein (HSP90) inhibitor. 17-DMAG is a more potent analog of geldanamycin. It inhibits cancer growth and promotes apoptosis in multiple cell lines. 17-DMAG is a more potent antitumor agent than 17-AAG.

17-DMAG is a more potent analog of geldanamycin. Inhibits cancer growth and promotes apoptosis in multiple cell lines. 17-DMAG is a more potent antitumor agent than 17-AAG.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable