모든 사진(3)
About This Item
실험식(Hill 표기법):
C12H12IN
CAS Number:
Molecular Weight:
297.13
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
저장 조건
desiccated
색상
white to beige
solubility
H2O: 10 mg/mL, clear
SMILES string
[I-].C[n+]1ccc(cc1)-c2ccccc2
InChI
1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
InChI key
RFDFRDXIIKROAI-UHFFFAOYSA-M
일반 설명
1-Methyl-4-phenylpyridinium (MPP+) acts as a selective ERα antagonist.induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.
애플리케이션
MPP+ iodide has been used:
- to induce oxidative stress in zebrafish embryos
- for the inhibition of glutamate uptake in mitochondria of astrocytes
- in testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells
생화학적/생리학적 작용
Active metabolite of dopaminergic neurotoxin MPTP
MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP.
주의사항
Photosensitive.
제조 메모
Solutions should be freshly prepared.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
이미 열람한 고객
Agnieszka Nikiforuk et al.
Frontiers in behavioral neuroscience, 11, 222-222 (2017-12-13)
Reduced cognitive abilities are often characterized by an impairment of flexibility, i.e., the ability to switch from learned rules or categories that were important in certain contexts to different new modalities that rule the task. Drugs targeting the dopamine transporter
JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss
Wang Q, et al.
Journal of Neuroinflammation, 15(1), 184-184 (2018)
1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide
Kalivendi SV, et al.
The Biochemical Journal, 371(1), 151-164 (2003)
Xi Yang et al.
Antimicrobial agents and chemotherapy, 60(10), 6260-6270 (2016-08-10)
Entecavir (ETV) is a first-line antiviral agent for the treatment of chronic hepatitis B virus infection. Renal excretion is the major elimination path of ETV, in which tubular secretion plays the key role. However, the secretion mechanism has not been
Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death
Sun L, et al.
Scientific Reports, 8(1), 383-383 (2018)
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