추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
lyophilized powder
분자량
antigen 180 kDa
종 반응성
mouse, rat, human
기술
immunohistochemistry: suitable
western blot: 1:200 using rat brain membranes
UniProt 수납 번호
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... CNTNAP2(26047)
mouse ... Cntnap2(66797)
rat ... Cntnap2(500105)
일반 설명
CASPR2 (Contactin-associated protein-like 2) belongs to CASPR family and neurexin superfamily.
면역원
peptide corresponding to amino acids residues 1315-1331 of human Caspr2.
애플리케이션
Anti-CASPR2 antibody has been used for immunohistochemitry and western blotting of proteins from mouse brain samples. It is also suitable for western blot analysis at a dilution of 1:200 by using rat brain membranes.
생화학적/생리학적 작용
CASPR2 (Contactin-associated protein-like 2) associates shaker like K+ channels in the juxtaparanodal region flanking nodes of Ranvier. It is expressed in different and distinct regions of the central nervous system (CNS) where it may plays an important role in cell recognition. CASPR and CASPR2 may interact with the actin-based cytoskeleton through cytoskeleton-associated protein 4.1B. CASPR2 is crucial for synapse formation and outgrowth of axon and dendrite. CASPR2 forms a complex with G-protein-coupled receptor 37 (GPR37) and multiple PDZ domain protein 1 (MUPP1). Disruption of the complex is linked with autism spectrum disorder (ASD). Genetic variations in CASPR2 are also associated with intellectual disability, epilepsy, schizophrenia and language disorders. It also regulates diet-induced obesity.
물리적 형태
Lyophilized from 0.4 mg/ml in phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose, and ≤0.1% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Yuko Tanabe et al.
Journal of neurochemistry, 134(4), 783-793 (2015-05-16)
Autism spectrum disorder (ASD) is a developmental brain disorder. Mutations in synaptic components including synaptic adhesion molecules have been found in ASD patients. Contactin-associated protein-like 2 (CASPR2) is one of the synaptic adhesion molecules associated with ASD. CASPR2 forms a
Matthew N Rasband et al.
The Journal of cell biology, 159(4), 663-672 (2002-11-20)
Voltage-dependent potassium channels regulate membrane excitability and cell-cell communication in the mammalian nervous system, and are found highly localized at distinct neuronal subcellular sites. Kv1 (mammalian Shaker family) potassium channels and the neurexin Caspr2, both of which contain COOH-terminal PDZ
S Poliak et al.
Neuron, 24(4), 1037-1047 (2000-01-07)
Rapid conduction in myelinated axons depends on the generation of specialized subcellular domains to which different sets of ion channels are localized. Here, we describe the identification of Caspr2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), and show that
Ivo Spiegel et al.
Molecular and cellular neurosciences, 20(2), 283-297 (2002-07-03)
The NCP family of cell-recognition molecules represents a distinct subgroup of the neurexins that includes Caspr and Caspr2, as well as Drosophila Neurexin-IV and axotactin. Here, we report the identification of Caspr3 and Caspr4, two new NCPs expressed in nervous
Natalia Denisenko-Nehrbass et al.
The European journal of neuroscience, 17(2), 411-416 (2003-01-25)
Caspr/paranodin, a neuronal transmembrane glycoprotein, is essential for the structure and function of septate-like paranodal axoglial junctions at nodes of Ranvier. A closely related protein, Caspr2, is concentrated in juxtaparanodal regions where it associates indirectly with the shaker-type potassium channels.
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