추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
peach to light pink
solubility
DMSO: ≥20 mg/mL
저장 온도
2-8°C
SMILES string
Cc1[nH]c2ccccc2c1CCNC(=O)c3cccs3
InChI
1S/C16H16N2OS/c1-11-12(13-5-2-3-6-14(13)18-11)8-9-17-16(19)15-7-4-10-20-15/h2-7,10,18H,8-9H2,1H3,(H,17,19)
InChI key
ACAKNPKRLPMONU-UHFFFAOYSA-N
생화학적/생리학적 작용
CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. Both classes of compounds inhibit formation of actin filament comet tails by Listeria and podosomes by monocytes.
CK-636 inhibits the activity of actin-related protein (Arp)2/3 complex; binds between Arp2 and Arp3, blocks movement of Arp2 and Arp3 into active conformations, inhibits ability to nucleate actin filaments.
가장 최신 버전 중 하나를 선택하세요:
Charlotte Ford et al.
PLoS pathogens, 14(5), e1007051-e1007051 (2018-05-05)
Pathogens hijack host endocytic pathways to force their own entry into eukaryotic target cells. Many bacteria either exploit receptor-mediated zippering or inject virulence proteins directly to trigger membrane reorganisation and cytoskeletal rearrangements. By contrast, extracellular C. trachomatis elementary bodies (EBs)
Liang Ma et al.
Cell research, 25(1), 24-38 (2014-10-25)
Cells communicate with each other through secreting and releasing proteins and vesicles. Many cells can migrate. In this study, we report the discovery of migracytosis, a cell migration-dependent mechanism for releasing cellular contents, and migrasomes, the vesicular structures that mediate
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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