C6019

Clotrimazole

98.5-100.5% (dry basis), powder, Ca²⁺-activated K⁺ channels inhibitor

• 동의어(들): 1-(o-Chloro-α,α-diphenylbenzyl)imidazole, 1-(o-Chlorotrityl)imidazole, 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole
• 실험식(Hill 표기법): C₂₂H₁₇ClN₂
• CAS Number: 23593-75-1
• Molecular Weight: 344.84
• EC Number: 245-764-8
• MDL number: MFCD00057220
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278327
• NACRES: NA.77

속성

• 제품명: Clotrimazole,
• 양식: powder
• Quality Level: 200
• 항생제 활성 스펙트럼: fungi
• 동작 모드: cell membrane | interferes; protein synthesis | interferes
• 주관자: Schering Plough
• SMILES string: Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
• InChI: 1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
• InChI key: VNFPBHJOKIVQEB-UHFFFAOYSA-N
• 유전자 정보: human ... ABCB1(5243) , CYP17A1(1586) , CYP3A4(1576) ; mouse ... Abcb1a(18671) , Abcb1b(18669)

설명

일반 설명

Chemical structure: imidazole

애플리케이션

Clotrimazole has been used:

• to study the upregulation of the gene ERG11 that codes for an azole target enzyme lanosterol demethylase, in Candida species, upon treatment with azole antibiotics
• to study the development of resistance in Candida species isolated from patients undergoing prolonged antifungal treatment
• to induce stress granules via mitochondrial stress
• for the inhibition of in vitro formation of high density sickle cells induced by treatment with 1-chloro-2,4-dinitrobenzene (CDNB)
• to inhibit cytochrome P450 enzyme in cell cultures

생화학적/생리학적 작용

Clotrimazole is a specific inhibitor of Ca²⁺-activated K⁺ channels. It is an antifungal azole. Clotrimazole is a derivative of imidazole and has similar antimicrobial action and activity to ketoconazole. It inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, altering cell membrane permeability.

특징 및 장점

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS07,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H302,H315,H319,H410
• 예방조치 성명서: P264 - P270 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves