C5851

CGP 35348 hydrate

≥97% (NMR), solid

• 동의어(들): (3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate
• 실험식(Hill 표기법): C₈H₂₀NO₄P · xH₂O
• CAS Number: 123690-79-9
• Molecular Weight: 225.22 (anhydrous basis)
• MDL number: MFCD11045877
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329775103
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (NMR)
• 양식: solid
• 저장 조건: desiccated
• 색상: white
• solubility: H₂O: >20 mg/mL
• 주관자: Novartis
• 저장 온도: −20°C
• SMILES string: O.CCOC(OCC)P(O)(=O)CCCN
• InChI: 1S/C8H20NO4P.H2O/c1-3-12-8(13-4-2)14(10,11)7-5-6-9;/h8H,3-7,9H2,1-2H3,(H,10,11);1H2
• InChI key: SRBHGEXMDCJOMS-UHFFFAOYSA-N

설명

애플리케이션

CGP 35348 hydrate has been used as a γ-aminobutyric acid-B (GABA_B) receptor inhibitor:

• to study its effects on intrinsic optical signal (IOS) in rat hippocampus
• alone or in combination with sodium salicylate to study its effects on auditory responses in the rat′s dorsal cortex of rat
• to study its effects on hepatocellular carcinoma cells (HCC)

생화학적/생리학적 작용

CGP 35348 is a γ-aminobutyric acid-B (GABA_B) receptor antagonist. It has a higher affinity towards post-versus presynaptic receptors that can penetrate the blood-brain barrier.

특징 및 장점

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAB Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

주의사항

Product is hygroscopic

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)