C4780

Coenzyme A sodium salt hydrate

BioReagent, suitable for cell culture

• 동의어(들): CoA Na₂
• 실험식(Hill 표기법): C₂₁H₃₆N₇O₁₆P₃S · xNa⁺ · yH₂O
• CAS Number: 55672-92-9
• Molecular Weight: 767.53 (anhydrous free acid basis)
• EC Number: 259-747-8
• MDL number: MFCD00079020
• UNSPSC 코드: 12352205
• PubChem Substance ID: 24892723
• NACRES: NA.75

속성

• 생물학적 소스: yeast
• 설명: cofactor for acyl transfer
• 제품 라인: BioReagent
• 분석: ≥85% (HPLC)
• 양식: powder
• 기술: cell culture | mammalian: suitable
• solubility: water: 50 mg/mL, clear, colorless to faintly yellow
• 저장 온도: −20°C
• SMILES string: [Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
• InChI: 1S/C21H36N7O16P3S.Na/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H
• InChI key: SYTRWOCXZXQBPW-CLVRNSBASA-M

설명

애플리케이션

Coenzyme A sodium salt hydrate has been used:

• in the branch chain aminotransferase enzymatic assay and protein determination
• in the assay for halogenation of pyrrolyl-S-Bmp1 (an acyl carrier protein (ACP)-thioesterase (TE) di-domain protein) by Bmp2
• as an extracellular coenzyme A (CoA) in in vitro and in vivo experiments to study alternative routes by which cells and organisms can obtain CoA

생화학적/생리학적 작용

Coenzyme A (CoA) is a ubiquitous cofactor that plays an important role in many metabolic pathways, mainly as acyl-CoA. It is essential for the tricarboxylic acid cycle, and the synthesis and oxidation of fatty acids. CoA facilitates acyl group transfers, especially in fatty acid and lipid metabolism reactions. It is associated with neurodegeneration, autophagy, protein acetylation, and signal transduction.

품질

Enzymatically assayed using phosphotransacetylase. Approx. 95% CoA-SH

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)