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C4493

Cucurbitacin I hydrate

Name: Cucurbitacin I hydrate
Brand: SIGMA

≥95% (HPLC), solid

동의어(들):

2,16α,20,25-Tetrahydroxy-9-methyl-19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione, Elatericin B, JSI-124, NSC 521777

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About This Item

실험식(Hill 표기법):

C₃₀H₄₂O₇ · xH₂O

CAS Number:

2222-07-3

Molecular Weight:

514.65 (anhydrous basis)

EC Number:

218-736-8

MDL number:

MFCD09971044

UNSPSC 코드:

12352200

PubChem Substance ID:

329775065

NACRES:

NA.77

추천 제품

Slide 1 of 10

1 of 10

Sigma-Aldrich

238590

Cucurbitacin I, Cucumis sativus L.

Sigma-Aldrich

C8499

Cucurbitacin B hydrate

Sigma-Aldrich

SML0577

Cucurbitacin E

PHL89464

Cucurbitacin I

PHL82226

Cucurbitacin B

PHL82510

Cyclopamine

Sigma-Aldrich

C2294

Cod liver oil fatty acid methyl esters

Y0001976

Deferiprone

Sigma-Aldrich

M3650

Methyl myristoleate

Sigma-Aldrich

L2037

β-Lapachone

Quality Level

100

분석

≥95% (HPLC)

양식

solid

색상

white to off-white

solubility

DMSO: >5 mg/mL

저장 온도

−20°C

SMILES string

O.CC(C)(O)\C=C\C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C

InChI

1S/C30H42O7.H2O/c1-25(2,36)12-11-21(33)30(8,37)23-19(32)14-27(5)20-10-9-16-17(13-18(31)24(35)26(16,3)4)29(20,7)22(34)15-28(23,27)6;/h9,11-13,17,19-20,23,31-32,36-37H,10,14-15H2,1-8H3;1H2/b12-11+;/t17-,19-,20+,23+,27+,28-,29+,30+;/m1./s1

InChI key

ZKDSPEWKSJCXQE-NEBRQAMTSA-N

생화학적/생리학적 작용

Cucurbitacin I (JSI-124) is a novel selective inhibitor of the janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway with anti-proliferative and anti-tumor properties.

Cucurbitacin I is a novel selective JAK/STAT3 inhibitor.

특징 및 장점

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

픽토그램

GHS06

신호어

Danger

유해 및 위험 성명서

H300

예방조치 성명서

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 1 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

가장 최신 버전 중 하나를 선택하세요:

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이미 열람한 고객

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1 of 9

Sigma-Aldrich

S7947

Stattic

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573096

STAT3 Inhibitor Peptide, Cell-Permeable

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SML1505

AZD1480

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F9057

FLLL31

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SML0330

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PHL80075

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Tyrphostin AG 490

Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis.

Ganchimeg Ishdorj et al.

Molecular cancer therapeutics, 9(12), 3302-3314 (2010-12-17)

Phosphorylation of STAT3 on serine 727 regulates gene expression and is found to be elevated in many B-leukemia cells including chronic lymphocytic leukemia (CLL). It is, however, unclear whether targeting STAT3 will be an effective antileukemia therapy. In this study

Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells.

Vivian W Y Lui et al.

Carcinogenesis, 30(12), 2085-2094 (2009-10-22)

Nasopharyngeal carcinoma (NPC) is an Asian-prevalent head and neck cancer with high invasiveness. Although several important risk factors for NPC development have been identified, there is currently no preventive strategy for NPC, even in endemic regions. Signal transducer and activator

Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133-positive cells.

Han-Shui Hsu et al.

Cancer, 117(13), 2970-2985 (2011-01-13)

Signal transducer and activator of transcription 3 (STAT3) signaling reportedly promotes tumor malignancy and recurrence in nonsmall cell lung cancer (NSCLC). It was demonstrated previously that the STAT3 pathway maintains the tumorigenicity and therapeutic resistance of malignant tumors as well

Cucurbitacin I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma--derived CD44(+)ALDH1(+) cells.

Yi-Wei Chen et al.

Molecular cancer therapeutics, 9(11), 2879-2892 (2010-11-11)

Head and neck squamous cell carcinoma (HNSCC) is a prevalent cancer worldwide. Signal transducers and activators of transcription 3 (STAT3) signaling is reported to promote tumor malignancy and recurrence in HNSCC. Cucurbitacins, triterpenoid derivatives, are strong STAT3 inhibitors with anticancer

Self-associating poly(ethylene oxide)-b-poly(alpha-cholesteryl carboxylate-epsilon-caprolactone) block copolymer for the solubilization of STAT-3 inhibitor cucurbitacin I.

Abdullah Mahmud et al.

Biomacromolecules, 10(3), 471-478 (2009-01-30)

An increase in the degree of chemical compatibility between drug and polymeric structure in the core has been shown to raise the encapsulation efficiency and lower the rate of drug release from polymeric micelles. In this study, to achieve an

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문서

JAKs

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주요 문서

Cucurbitacin I hydrate

≥95% (HPLC), solid

About This Item

추천 제품

속성

Quality Level

분석

양식

색상

solubility

저장 온도

SMILES string

InChI

InChI key

설명

생화학적/생리학적 작용

특징 및 장점

안전성 정보

픽토그램

신호어

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Storage Class Code

WGK

Flash Point (°F)

Flash Point (°C)

개인 보호 장비

문서

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