C2806

Calcitonin Gene Related Peptide Fragment 8-37 human

≥97% (HPLC), powder

• 동의어(들): α-CGRP 8-37, FBHuman
• 실험식(Hill 표기법): C₁₃₉H₂₃₀N₄₄O₃₈
• CAS Number: 119911-68-1
• Molecular Weight: 3125.59
• MDL number: MFCD00133153
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329774752
• NACRES: NA.32

속성

• Quality Level: 200
• 분석: ≥97% (HPLC)
• 양식: powder
• 구성: Peptide content, ~70%
• UniProt 수납 번호: P06881; P01258
• 저장 온도: −20°C
• SMILES string: CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc4ccccc4)C(N)=O
• InChI: 1S/C139H230N44O38/c1-66(2)48-86(161-102(193)60-155-113(197)74(17)159-120(204)87(49-67(3)4)168-118(202)83(40-31-45-152-138(147)148)163-123(207)90(53-80-57-151-65-158-80)173-136(220)111(77(20)188)182-131(215)105(145)69(7)8)121(205)169-88(50-68(5)6)122(206)176-96(64-186)129(213)165-84(41-32-46-153-139(149)150)119(203)175-94(62-184)115(199)156-58-101(192)154-59-104(195)177-107(71(11)12)134(218)179-108(72(13)14)133(217)166-82(39-28-30-44-141)117(201)171-91(54-98(142)189)125(209)172-92(55-99(143)190)124(208)170-89(52-79-36-25-22-26-37-79)126(210)180-109(73(15)16)137(221)183-47-33-42-97(183)130(214)181-110(76(19)187)135(219)174-93(56-100(144)191)127(211)178-106(70(9)10)132(216)157-61-103(194)162-95(63-185)128(212)164-81(38-27-29-43-140)116(200)160-75(18)114(198)167-85(112(146)196)51-78-34-23-21-24-35-78/h21-26,34-37,57,65-77,81-97,105-111,184-188H,27-33,38-56,58-64,140-141,145H2,1-20H3,(H2,142,189)(H2,143,190)(H2,144,191)(H2,146,196)(H,151,158)(H,154,192)(H,155,197)(H,156,199)(H,157,216)(H,159,204)(H,160,200)(H,161,193)(H,162,194)(H,163,207)(H,164,212)(H,165,213)(H,166,217)(H,167,198)(H,168,202)(H,169,205)(H,170,208)(H,171,201)(H,172,209)(H,173,220)(H,174,219)(H,175,203)(H,176,206)(H,177,195)(H,178,211)(H,179,218)(H,180,210)(H,181,214)(H,182,215)(H4,147,148,152)(H4,149,150,153)/t74-,75-,76+,77+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,105-,106-,107-,108-,109-,110-,111-/m0/s1
• InChI key: NDACAFBDTQIYCQ-YVQXRMNASA-N
• 유전자 정보: human ... CALCA(796)

설명

Amino Acid Sequence

Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2

일반 설명

Calcitonin-related peptide α (CALCA) is a 37-amino-acid vasoactive neuropeptide. It is scattered in the central and peripheral nervous systems. The calcitonin/calcitonin gene-related peptide gene complex codes for a small family of peptides: calcitonin, katacalcin and CALCA. This vasodilator is potent than other vasodilators, such as adenosine, substance P or acetylcholine. CALCA gene is located on human chromosome 11p15.2-p15.1. Procalcitonin (PCT) is a calcitonin (CT) precursor.

애플리케이션

Calcitonin Gene Related Peptide Fragment 8-37 human has been used in the administration of drugs. It has been used to test the hypothesis that calcitonin gene‐related peptide (CGRP) plays a role in the fetal cardiovascular and metabolic defense responses to acute hypoxaemia by affecting sympathetic outflow.

생화학적/생리학적 작용

Selective competitive antagonist at CGRP receptors, but not at calcitonin receptors.
Calcitonin gene-related peptide (CALCA) serves as a proangiogenic growth factor in the development of human placenta. Mutations of CALCA gene is associated with Parkinson′s disease, ovarian cancer and essential hypertension. CALCA induce vascular endothelial cell proliferation, migration and capillary-like tube formation.

기타 정보

Lyophilized from 0.1% TFA in H2O

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)