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Merck
모든 사진(3)

주요 문서

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C2538

Sigma-Aldrich

Carboplatin

동의어(들):

cis-Diammine(1,1-cyclobutanedicarboxylato) platinum

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모든 사진(3)

About This Item

Linear Formula:
[C4H6(CO2)2]Pt(NH3)2
CAS Number:
41575-94-4
Molecular Weight:
371.25
EC Number:
255-446-0
MDL number:
MFCD00070464
UNSPSC 코드:
12352200
PubChem Substance ID:
24278303
NACRES:
NA.77

양식

powder

Quality Level

100

항생제 활성 스펙트럼

neoplastics

주관자

Bristol-Myers Squibb

SMILES string

N.N.O=C1O[Pt]OC(=O)C12CCC2

InChI

1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2

InChI key

OLESAACUTLOWQZ-UHFFFAOYSA-L

유사한 제품을 찾으십니까? 방문 제품 비교 안내

일반 설명

Carboplatin is used to treat testicular, ovarian and breast cancer.

애플리케이션

Carboplatin has been used:
  • in chemotherapy-induced thrombocytopenia mouse model and treatment
  • to induce cell death in a large subset of colorectal cancer cells
  • in the evaluation of cell proliferation and chemosensitivity
  • as a positive control for suppressed cell growth

생화학적/생리학적 작용

Carboplatin is a platinum-based antineoplastic drug that damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death.

특징 및 장점

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

픽토그램

Health hazardExclamation mark
GHS08,GHS07

신호어

Danger

유해 및 위험 성명서

H302 + H312 + H332,H317,H334,H340,H360

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
MKCK1243
MKCK1244
MKCF9647
MKCC6970
MKBZ8825V

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

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Cisplatin United States Pharmacopeia (USP) Reference Standard

USP

1134357

Cisplatin

Gemcitabine hydrochloride ≥98% (HPLC)

Sigma-Aldrich

G6423

Gemcitabine hydrochloride

Nedaplatin

Sigma-Aldrich

SML2514

Nedaplatin

Oxaliplatin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1528

Oxaliplatin

Oxaliplatin European Pharmacopoeia (EP) Reference Standard

Y0000271

Oxaliplatin

Chlorambucil

Sigma-Aldrich

C0253

Chlorambucil

Paclitaxel from semisynthetic, ≥98%

Sigma-Aldrich

T7191

Paclitaxel

Furqan Shaikh et al.
Pediatric blood & cancer, 60(4), 587-592 (2012-09-15)
While cisplatin is considered superior to carboplatin for the treatment of malignant germ cell tumors (MGCTs) in adults, pediatric oncology collaborative groups still remain concerned about the late effects of cisplatin in children. We performed a literature search to identify
Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells
Aleksic T and Feller SM
Cell communication and signaling : CCS, 6(1), 8-8 (2008)
Selective toxicity of rose bengal to ovarian cancer cells in vitro
Koevary SB
International Journal of Physiology, Pathophysiology and Pharmacology, 4(2), 99-99 (2012)
Ian M Collins et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 21(7), 1213-1218 (2011-06-28)
Carboplatin is one of the most effective chemotherapeutic drugs for the treatment of ovarian cancer. It has simple pharmacokinetics and a predictable toxicity profile. The dose can be calculated effectively based on a patient's renal function as defined by the
Nikola A Bowden
Cancer letters, 346(2), 163-171 (2014-01-28)
Platinum based therapy is one of the most effectively used chemotherapeutic treatments for cancer. The mechanism of action of platinum compounds is to damage DNA and drive cells into apoptosis. The most commonly used platinum containing agents are cis-diammine-dichloroplatinum (II)]
모든 관련된 서류 보기

문서

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

관련 콘텐츠

Discover Bioactive Small Molecules for Cell Cycle Research

n proliferating cells, the cell cycle consists of four phases. Gap 1 (G1) is the interval between mitosis and DNA replication that is characterized by cell growth. Replication of DNA occurs during the synthesis (S) phase, which is followed by a second gap phase (G2) during which growth and preparation for cell division occurs. Together, these three stages comprise the interphase phase of the cell cycle. Interphase is followed by the mitotic (M) phase.

Discover Bioactive Small Molecules for Apoptosis

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of multicellular organisms, apoptosis is tightly regulated through two principal pathways by a number of regulatory and effector molecules.

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

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