B7273

Bezafibrate

≥98%, solid

• 동의어(들): 2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid
• 실험식(Hill 표기법): C₁₉H₂₀ClNO₄
• CAS Number: 41859-67-0
• Molecular Weight: 361.82
• EC Number: 255-567-9
• MDL number: MFCD00078970
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24891983
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥98%
• 양식: solid
• solubility: DMF: soluble; deionized water: insoluble; methanol: soluble
• 주관자: Roche
• SMILES string: CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(O)=O
• InChI: 1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24)
• InChI key: IIBYAHWJQTYFKB-UHFFFAOYSA-N
• 유전자 정보: human ... HBA2(3040) , PPARA(5465) , PPARD(5467) , PPARG(5468) ; mouse ... Ppara(19013) , Ppard(19015) , Pparg(19016)

설명

애플리케이션

Bezafibrate has been used:

• a supplement in the standard diet (SD) for mice to study its effect on diabetes
• to evaluate its effect on hepatitis C virus (HCV) assembly and secretion
• to evaluate its effect on gonadal steroidogenesis and spermatogenesis of zebrafish and also used as standard for HPLC

생화학적/생리학적 작용

Bezafibrate has the ability to repress HCV assembly and secretion. It is used to treat dyslipidemia.

Bezafibrate is a peroxisome proliferator-activated receptor agonist for PPARα, PPARδ, and PPARγ. Lipoprotein lipase (LPL) activator.

The peroxisome proliferator-activated receptor (PPAR) is a member of the steroid nuclear receptor superfamily. Bezafibrate is a peroxisome proliferator-activated receptor agonist for PPARα, PPARδ, and PPARγ. Lipoprotein lipase (LPL) activator.
PPARgamma agonists, including Bezafibrate, have beneficial effects in the suppression of the inflammatory response during RSV infection and therefore might have clinical efficacy in the course of severe RSV-infection.

특징 및 장점

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves