추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
H2O: soluble 15 mg/mL, clear
주관자
GlaxoSmithKline
SMILES string
OC(=O)\C=C/C(O)=O.CC1N(CC2=NCCN2)Cc3ccccc13
InChI
1S/C13H17N3.C4H4O4/c1-10-12-5-3-2-4-11(12)8-16(10)9-13-14-6-7-15-13;5-3(6)1-2-4(7)8/h2-5,10H,6-9H2,1H3,(H,14,15);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key
DDIQGSUEJOOQQQ-BTJKTKAUSA-N
관련 카테고리
생화학적/생리학적 작용
BRL 44408 maleate is a selective α2A-adrenoceptor antagonist.
특징 및 장점
This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
법적 정보
Sold under agreement from GlaxoSmithKline
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Zoltán S Zádori et al.
Neurochemistry international, 51(5), 297-305 (2007-08-01)
The inhibitory effect of clonidine (non-selective alpha2-adrenoceptor agonist) and oxymetazoline (alpha2A-adrenoceptor selective agonist) was compared on basal and stimulated gastric motor activity (gastric tone and contractions) using the balloon method in the rat. It was shown that oxymetazoline (0.2-1.7 micromol/kg
Mu-huo Ji et al.
Cytokine, 60(3), 639-645 (2012-09-11)
To investigate the effects of α2A-adrenoreceptor blockade on acute lung injury (ALI) and high mobility group box-1 protein (HMGB1) expression in a rat model of sepsis. Sepsis was induced in male rats by cecal ligation and puncture (CLP). Thirty adult
Junta Imaki et al.
Neuroscience letters, 454(2), 143-147 (2009-05-12)
We examined the effects of JP-1302 (a selective alpha2C antagonist), BRL-44408 (a selective alpha2A antagonist) and yohimbine (a non-selective alpha2 antagonist) on haloperidol-induced bradykinesia and catalepsy in mice to elucidate the role of alpha2 adrenoceptor subtypes in modifying extrapyramidal motor
Shawquia Young et al.
Basic & clinical pharmacology & toxicology, 107(2), 690-697 (2010-04-01)
Previously, we reported that antinociceptive synergism of a 5-HT(3)/alpha(2)-adrenoceptor ligand MD-354 (m-chlorophenylguanidine) and clonidine combination occurs, in part, through a 5-HT(3) receptor antagonist mechanism. In the present investigation, a possible role for alpha(2)-adrenoceptors was examined. Mechanistic studies using yohimbine (a
Roberto T Sudo et al.
The journal of pain : official journal of the American Pain Society, 11(1), 71-78 (2009-10-27)
Finding new chemicals or adjuvants with analgesic effects in the central nervous system is clinically relevant due to the limited number of drugs with these properties. Here, we present PT-31, which is chemically related to 3-benzyl-imidazolidine, with an analgesic profile
문서
α2-Adrenoceptors
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