추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
IgG fraction of antiserum
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
20 kDa
종 반응성
human
농도
0.5 mg - 1 mg/mL
기술
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... OLR1(4973)
면역원
Synthetic peptide directed towards the N terminal region of human OLR1
애플리케이션
Anti-OLR1 antibody produced in rabbit is suitable for western blotting at a concentration of 2.5μg/ml.
생화학적/생리학적 작용
Oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1; LOX1) is a receptor for low density lipoprotein (LDL) that belongs to C-type lectin superfamily. It binds, internalizes and degrades oxidized LDL and has a role as scavenger receptor. It may be involved in the regulation of Fas-induced apoptosis. Mutations in OLR1 gene are associated with atherosclerosis and myocardial infarction.
서열
Synthetic peptide located within the following region: QANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQ
물리적 형태
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Zufeng Ding et al.
Scientific reports, 3, 2091-2091 (2013-06-29)
Here we demonstrate that "concentration polarization" of ox-LDL enhances LOX-1 expression and ox-LDL uptake. It damages cell surface heparan sulfate proteoglycans (HSPG) and activates LOX-1 dependent autophagy and apoptosis. We also show that ox-LDL concentration polarization occurs on the surface
Angela Pirillo et al.
Mediators of inflammation, 2013, 152786-152786 (2013-08-13)
Oxidized low-density lipoprotein (OxLDL) contributes to the atherosclerotic plaque formation and progression by several mechanisms, including the induction of endothelial cell activation and dysfunction, macrophage foam cell formation, and smooth muscle cell migration and proliferation. Vascular wall cells express on
Ming-Sheng Zhou et al.
American journal of hypertension, 27(6), 873-880 (2014-01-15)
Current treatment for the secondary prevention of cardiovascular diseases frequently involves the prescription of several combination therapies, particularly antihypertensive medications and HMG-CoA reductase inhibitor. We have previously shown that in salt-sensitive hypertension either a statin or the calcium channel blocker
Miyuki Kumano-Kuramochi et al.
Biochemical and biophysical research communications, 434(3), 594-599 (2013-04-16)
Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is an endothelial scavenger receptor that is important for oxidized low-density lipoprotein uptake. LOX-1 functions as an oligomer; however, little is known about the oligomeric complex and ligand processing after recognition by LOX-1.
Deenadayalan Bakthavatsalam et al.
FEBS letters, 588(13), 2133-2140 (2014-05-23)
Lectin-like oxidized low-density lipoprotein receptor (LOX-1) is a scavenger receptor that binds oxidized low-density lipoprotein (OxLDL) and has a role in atherosclerosis development. The N-terminus intracellular region (cytoplasmic domain) of LOX-1 mediates receptor internalization and trafficking, potentially through intracellular protein
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