AV38613

Anti-NFIL3 antibody produced in rabbit

IgG fraction of antiserum

• 동의어(들): Anti-Nuclear factor, interleukin 3 regulated
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: IgG fraction of antiserum
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: 51 kDa
• 종 반응성: human
• 농도: 0.5 mg - 1 mg/mL
• 기술: immunohistochemistry: suitable; western blot: suitable
• NCBI 수납 번호: NP_005375
• UniProt 수납 번호: Q14211
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... NFIL3(4783)

설명

일반 설명

Nuclear factor, interleukin 3 regulated (NFIL3, E4BP4) is a transcription factor involved in development of haematopoietic lineages. NFIL3/E4BP4 is required for development of NK cells and CD8α(+) conventional dendritic cells, and myeloid lineage commitment. NFIL3/E4BP4 also facilitates macrophage activation, polarisation of CD4(+) T cell responses and B cell class switching to IgE.

특이성

Anti-NFIL3 polyclonal antibody reacts with human, bovine, and canine nuclear factor, interleukin 3 regulated proteins.

면역원

Synthetic peptide directed towards the N terminal region of human NFIL3

애플리케이션

Anti-NFIL3 polyclonal antibody is used to tag nuclear factor, interleukin 3 regulated for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of nuclear factor, interleukin 3 regulated in haematopoietic lineages development and specialized immune function regulation.

생화학적/생리학적 작용

NFIL3 is a basic leucine zipper (bZIP) transcription factor that represses or activates transcription in non-osteoblastic cells. NFIL3 play a role in attenuation of PTH target gene transcription in osteoblasts. NFIL3 repression domain interacts specifically with the TBP binding repressor protein Dr1.Glucocorticoid-mediated upregulation of the bZIP transcriptional repressor gene, NFIL3, is dependent on [Ca2+]i levels, and correlates with Glucocorticoid-evoked apoptosis of Glucocorticoid-sensitive CEM-C7-14 cells. NFIL3 is involved in a distinct growth factor-regulated signaling pathway that is responsible for the survival of early B-cell progenitors, and whose alteration by E2A-HLF leads to childhood B lineage leukemia.

서열

Synthetic peptide located within the following region: MQLRKMQTVKKEQASLDASSNVDKMMVLNSALTEVSEDSTTGEDVLLSEG

물리적 형태

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable