A8003
Allopurinol
xanthine oxidase inhibitor
동의어(들):
1H-Pyrazolo(3,4-d)pyrimidin-4-ol, 4-Hydroxypyrazolo(3,4-d)pyrimidine, 4-Hydroxypyrazolo[3,4-d]pyrimidine, HPP
로그인조직 및 계약 가격 보기
모든 사진(3)
About This Item
실험식(Hill 표기법):
C5H4N4O
CAS Number:
Molecular Weight:
136.11
EC Number:
MDL number:
UNSPSC 코드:
12352202
PubChem Substance ID:
NACRES:
NA.77
추천 제품
생물학적 소스
synthetic (organic)
Quality Level
분석
≥99% (TLC)
양식
powder
mp
>300 °C (lit.)
solubility
1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
저장 온도
room temp
SMILES string
O=C1NC=Nc2[nH]ncc12
InChI
1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)
InChI key
OFCNXPDARWKPPY-UHFFFAOYSA-N
유전자 정보
human ... XDH(7498)
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애플리케이션
Allopurinol has been used:
- to decrease the uric acid levels and study its effect on renal injury and inflammation in mice
- as a xanthine oxidase inhibitor to test panton-valentine leukocidin (PVL) neutrophil extracellular traps (NETosis) dependence on different enzymes, channels, or organelles using human polymorphonuclear cells (hPMNs)
- as a reference standard to study the inhibitory effect of olive leaf components on xanthine oxidase in vitro
Allopurinol is suitable for:
- intravenous injection in mice for inhibition of xanthine oxidase
- use as an inhibitor of xanthine oxidase
- use as a positive control in xanthine oxidase inhibition assay
- use in the preparation of University of Wisconsin solution for osmotic stabilization to enhance the density differences between islets and acinar fragments during porcine islet purification
생화학적/생리학적 작용
Allopurinol is a purine analog that inhibits certain enzymes involved in purine metabolism. It is known to reduce the synthesis of uric acid in the body. Allopurinol mediated inhibition of xanthine oxidase exhibits anti-inflammatory effects on atherosclerosis, acute lung injury, and congestive heart failure.
Inhibitor of xanthine oxidase and de novo pyrimidine biosynthesis. A classical agent in treatment of hyperuricemia and gout.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 3 Oral - Skin Sens. 1
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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