A4559

Amyloid β-Protein Fragment 25-35

≥97% (HPLC)

• 실험식(Hill 표기법): C₄₅H₈₁N₁₃O₁₄S
• CAS Number: 131602-53-4
• Molecular Weight: 1060.27
• MDL number: MFCD00133076
• UNSPSC 코드: 12352202
• PubChem Substance ID: 24890880
• NACRES: NA.32

속성

• Quality Level: 200
• 분석: ≥97% (HPLC)
• 양식: powder
• 구성: Protein Content, ≥80%
• UniProt 수납 번호: P05067
• 저장 온도: −20°C
• SMILES string: CCC(C)C(NC(=O)C(NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)CN)C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(O)=O
• InChI: 1S/C45H81N13O14S/c1-9-24(5)36(43(69)50-21-35(63)52-29(17-23(3)4)40(66)55-28(45(71)72)14-16-73-8)58-44(70)37(25(6)10-2)57-38(64)26(7)51-34(62)20-49-39(65)27(13-11-12-15-46)54-41(67)30(18-32(48)60)56-42(68)31(22-59)53-33(61)19-47/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,69)(H,51,62)(H,52,63)(H,53,61)(H,54,67)(H,55,66)(H,56,68)(H,57,64)(H,58,70)(H,71,72)
• InChI key: WIHBNMPFWRHGDF-UHFFFAOYSA-N
• 유전자 정보: human ... APP(351)

설명

Amino Acid Sequence

Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met

일반 설명

Amyloid β-Protein Fragment 25-35 (Aβ25-35) is derived from the amyloid-β protein.amyloid-β protein, which is mapped to human chromosome 21q21. Aβ25-35 lacks the N-terminal domain and the metal binding site and is majorly generated by proteolytic cleavage of Aβ(1−40) peptides. It has a β-sheet and β-turn structure.

애플리케이션

Amyloid β-Protein Fragment 25-35 has been used:

• to induce neurotoxicity in cortical cultures
• to induce Alzheimer′s disease in rat model
• to induce apoptosis in mesenchymal stem cells (MSCs)

생화학적/생리학적 작용

Amyloid β-Protein Fragment 25-35 (Aβ25-35) is involved in the pathogenesis of Alzheimer′s disease. Inhibitors of this transition may serve as a potential agent in managing Alzheimer′s disease. It is present in the subiculum and entorhinal cortex neurons of Alzheimer′s brain samples and inclusion-body myositis (IBM) muscle. It binds to receptors present in microglia and is capable of lipid membrane insertion. The functional domain sequence of Aβ comprising of sequence GSNKGAIIGLM elicits neurotrophic and neurotoxic effects. Aβ25-35 exhibits rapid aggregation and displays age dependant neurotoxicity.

기타 정보

Lyophilized from 0.1% TFA in H2O

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)