모든 사진(1)
About This Item
실험식(Hill 표기법):
C6H16N6 · H2O4S
CAS Number:
Molecular Weight:
270.31
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
생물학적 소스
synthetic (organic)
Quality Level
분석
≥98% (TLC)
양식
powder
mp
>280 °C
solubility
1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
SMILES string
OS(O)(=O)=O.NC(=N)NCCCCNC(N)=N
InChI
1S/C6H16N6.H2O4S/c7-5(8)11-3-1-2-4-12-6(9)10;1-5(2,3)4/h1-4H2,(H4,7,8,11)(H4,9,10,12);(H2,1,2,3,4)
InChI key
RWTGFMPOODRXIM-UHFFFAOYSA-N
유전자 정보
human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRINA(2907)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
애플리케이션
Arcaine sulfate salt has been used as an N-methyl-d-aspartate (NMDA) receptor effector/antagonist:
- to evaluate its effects on the acquisition of electrical kindling of the amygdala
- to compare its effects with agmatine and MK801 on NMDA- or glutamate-induced neuronal damage
- to study its effects on cell-free translation of synthetic polynucleotide
생화학적/생리학적 작용
Arcaine sulfate salt (1,4-diguanidinobutane), a polyamine, is an antagonist of the polyamine binding site of the N-methyl-d-aspartate (NMDA) receptor. Arcaine, an agmatine analog, along with ifenprodil, might have a possibility for therapeutic management in epileptic disorders.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Nádia Aléssio Velloso Bellé et al.
Brain research, 1008(2), 245-251 (2004-05-18)
Polyamines, among other functions, are considered to act as a free radical scavenger and antioxidant. The quinolinic acid (QA), sodium nitroprusside (SNP) and iron (Fe+2) stimulate production of free radicals and lipid peroxidation. In the present study, we investigated the
Arcaine is a competitive antagonist of the polyamine site on the NMDA receptor.
I J Reynolds
European journal of pharmacology, 177(3), 215-216 (1990-02-27)
Raquele Kipper Mariani et al.
Psychopharmacology, 215(3), 483-491 (2011-03-02)
Arcaine is a competitive antagonist of the polyamine binding site at the N-methyl-D-aspartic acid receptor which induces state-dependent recall. However, no study has addressed the involvement of other neurotransmitter/neuromodulators in arcaine-induced state dependency. The current study investigates whether the opioid
R C Araneda et al.
Biophysical journal, 76(6), 2899-2911 (1999-06-04)
Polyamines such as spermine are thought to be endogenous regulators of NMDA (N-methyl-D-aspartate)-type glutamate receptors. Polyamine block of NMDA receptors was studied in excised outside-out patches from rat hippocampal neurons and Xenopus oocytes expressing recombinant receptors. Extracellular spermine and arcaine
J F Atkins et al.
The Journal of biological chemistry, 250(14), 5688-5695 (1975-07-25)
Addition of the polyamines spermidine, spermine, or putrescine to a fractionated mammalian cell-free protein-synthesis system programmed by a variety of mRNAs results in a 3- to 5-fold stimulation of amino acid incorporation over that found in the absence of added
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