추천 제품
생물학적 소스
bovine blood
Quality Level
분석
≥90% (SDS-PAGE)
양식
powder
품질
2×cryst.
lyophilized
분자량
Mr ~64500
기술
UV/Vis spectroscopy: suitable
불순물
salt, none detected
~0.3% Fe
손실
≤8% loss on drying
저장 온도
2-8°C
유전자 정보
cow ... HBA1(281221) , HBB(280813) , HBE2(513240) , HBE4(513108) , HBG(511735) , alpha globin(512439)
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일반 설명
Hemoglobin (Hb) is the protein responsible for storage and transport of oxygen and other gaseous ligands in red blood cells (RBC). Hb is also the pioneer material for synthesis of Hb-based oxygen carriers (HBOCs) that can be used as substitutes for RBC.
애플리케이션
The solubility of α-elastin has been applied to construction of elastin-mimetic biomaterials.
생화학적/생리학적 작용
Oxygen transporter, NO scavenger
Oxygen transporter. The Fe2+/Fe3+ balance is a physiological indicator of blood oxygenation; deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to NO, a vasodilator which enhances blood flow to oxygen-deprived tissues.
주의사항
Since native hemoglobin is readily oxidized in air, these preparations may be predominantly methemoglobin.
기타 정보
Review: Oxygen carrier proteins
Sales restrictions may apply
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Paul W Buehler et al.
Biomaterials, 31(13), 3723-3735 (2010-02-13)
Hemoglobin-based oxygen carriers (HBOC) are currently being developed as red blood cell (RBC) substitutes for use in transfusion medicine. Despite significant commercial development, late stage clinical results of polymerized hemoglobin (PolyHb) solutions hamper development. We synthesized two types of PolyHbs
M. Brunori et al.
Topics in Molecular and Structural Biology, 7, 263-263 (1985)
R Bokiniec et al.
Advances in medical sciences, 57(2), 348-355 (2012-11-20)
The aim of this study was to determine brain oxygenation in full-term and preterm neonates using near infrared spectroscopy. A total of 88 full-term and preterm newborn infants without hypoxic-ischaemic disorders admitted to the NICU were examined using NIRS on
Jae G Kim et al.
Journal of biomedical optics, 17(10), 105005-105005 (2012-12-12)
Noninvasive near infrared spectroscopy measurements were performed to monitor cyanide (CN) poisoning and recovery in the brain region and in foreleg muscle simultaneously, and the effects of a novel CN antidote, sulfanegen sodium, on tissue hemoglobin oxygenation changes were compared
Enrico Bucci et al.
Biochemistry, 52(24), 4149-4156 (2013-05-29)
Hill's plots of oxygen binding isotherms reveal the presence of a transition between two different oxygen affinities at the beginning and end of the isotherm. They correspond to the two conformations anticipated by the MWC model, namely, the T and
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