추천 제품
생물학적 소스
Porcine brain
microbial (Corynebacterium sp)
synthetic
Quality Level
분석
≥90% (HPLC)
양식
powder
solubility
H2O: 50 mg/mL, clear, colorless
배송 상태
dry ice
저장 온도
−20°C
SMILES string
[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1
InChI
1S/C10H15N5O11P2.2Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;/q;2*+1/p-2/t3-,5-,6-,9-;;/m1../s1
InChI key
LTZCGDIGAHOTKN-LGVAUZIVSA-L
일반 설명
Guanosine 5′-diphosphate (GDP) is a purine nucleotide and is interconvertible to guanosine by the action of ectonucleotidases and by nucleoside phosphorylase into guanine. GDP is majorly acted upon by 5′‐ectonucleotidases in neuronal cells.
애플리케이션
Guanosine 5′-diphosphate (GDP) is used as a substrate of pyruvate kinase to produce GTP in support of RNA biosyntheis. GDP is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). GDP is also used to study cell signaling processes mediate by guanine nucleotide exchange factors.
Guanosine 5′-diphosphate disodium salt has been used:
- in fluorescent metal nanoclusters selectivity of guanosine 3′-diphosphate-5′-di(tri)phosphate, ppGpp
- in screening of fluorescence emission of hypocrellin A-zinc complex
- as a component of assay buffers in the autoradiography of mice brain sections
생화학적/생리학적 작용
Guanosine based nucleosides play a key role in multiple cellular processes and generation growth factors. Elevated levels of guanosine 5′-diphosphate (GDP) is associated with the pathogenesis of neurological disorders. GDP is bound to G protein . G protein coupled receptors (GPCRs) activate G proteins by exchanging the bound GDP to GTP. GDP is potent inhibitor agent of hepcidin- ferroportin complex and may be effective for promoting erythropoiesis and treating anemia of inflammation(AI).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
이미 열람한 고객
Highly selective detection of bacterial alarmone ppGpp with an off-on fluorescent probe of copper-mediated silver nanoclusters
Zhang P, et al.
Biosensors And Bioelectronics, 49, 433-437 (2013)
Perinatal vs genetic programming of serotonin states associated with anxiety
Altieri SC, et al.
Neuropsychopharmacology, 40(6), 1456-1456 (2015)
Guanosine phosphate binding protein coupled receptors in prostate cancer: a review
Raj GV, et al.
The Journal of Urology, 167(3), 1458-1463 (2002)
Guanosine behind the scene
Ciruela, Francisco
Journal of Neurochemistry, 126(4), 425-427 (2013)
Michael P East et al.
Seminars in cell & developmental biology, 22(1), 3-9 (2010-07-20)
Arf GAPs (ADP-ribosylation factor GTPase-activating proteins) are essential components of Arf (ADP-ribosylation factor) signaling pathways. Arf GAPs stimulate the hydrolysis of GTP to GDP to transition Arf from the active, GTP bound, state to the inactive, GDP bound, state. Based
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