추천 제품
vapor density
3.9 (vs air)
Quality Level
vapor pressure
97.5 mmHg ( 20 °C)
제품 라인
ReagentPlus®
분석
99%
양식
liquid
불순물
≤0.05% water
refractive index
n20/D 1.3 (lit.)
pH
1 (10 g/L)
bp
72.4 °C (lit.)
mp
−15.4 °C (lit.)
solubility
ethanol: soluble 0.33 mL/mL
density
1.489 g/mL at 20 °C (lit.)
SMILES string
OC(C(F)(F)F)=O
InChI
1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)
InChI key
DTQVDTLACAAQTR-UHFFFAOYSA-N
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
Trifluoroacetic acid (TFA) is an organofluorine compound used as a reagent in organic synthesis for various acid-catalyzed reactions such as ring-opening of epoxides, biomimetic cyclization, Cope rearrangements, and natural product synthesis. TFA′s physicochemical characteristics provide advantages over other acids because of its high volatility, solubility in organic solvents, and acidic strength. When TFA is used as a reagent the product isolation is simple by evaporation due to its very high volatility. Less volatile acids such as sulfuric acid or p-toluenesulfonic acid may require neutralization or an extractive workup.
애플리케이션
Trifluoroacetic acid can be used as a reagent:
TFA can also be used as:
- For the cleavage of nitrogen and oxygen protecting groups such as N-Boc, N-benzyloxymethyl, benzyl ether, p-methoxybenzyl ether, t-butyl ether, t-butyloxymethyl ether, triphenylmethyl ether, and dimethyl acetals.
- In the Baeyer–Villiger oxidation reactions in combination with sodium percarbonate.,·
- For the C-H trifluoromethylation of arenes.
TFA can also be used as:
- A solvent in atom transfer cyclization reactions and polymer processes.
- A catalyst in the synthesis of ε-caprolactam via Beckmann rearrangement of cyclohexanone oxime in aprotic solvents.
포장
1mL in each ampule.
법적 정보
ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A
Storage Class Code
8A - Combustible corrosive hazardous materials
WGK
WGK 2
이미 열람한 고객
Organocatalyzed Beckmann rearrangement of cyclohexanone oxime by trifluoroacetic acid in aprotic solvent
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프로토콜
Fmoc resin cleavage and deprotection follows the difficult task of detaching the peptide from the resin support and removing all the side-chain protecting groups of the amino acid residues to yield the desired peptide.
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