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주요 문서

Y0000317

Mesna impurity D

European Pharmacopoeia (EP) Reference Standard

동의어(들):

2,2′-Dithiobisethanesulfonic acid, 2,2′-(Disulphanediyl)bis(ethanesulphonic acid)

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About This Item

실험식(Hill 표기법):
C4H10O6S4
CAS Number:
Molecular Weight:
282.38
UNSPSC 코드:
41116107
NACRES:
NA.24

Grade

pharmaceutical primary standard

API family

mesna

제조업체/상표

EDQM

응용 분야

pharmaceutical (small molecule)

형식

neat

저장 온도

2-8°C

SMILES string

[Na+].[Na+].[S](=O)(=O)([O-])CCSSCC[S](=O)(=O)[O-]

InChI

1S/C4H10O6S4.2Na/c5-13(6,7)3-1-11-12-2-4-14(8,9)10;;/h1-4H2,(H,5,6,7)(H,8,9,10);;/q;2*+1/p-2

InChI key

KQYGMURBTJPBPQ-UHFFFAOYSA-L

일반 설명

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

애플리케이션

Mesna impurity D EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

포장

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

기타 정보

Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Miranda Verschraagen et al.
Journal of pharmaceutical sciences, 92(5), 1040-1050 (2003-04-25)
Sensitive, accurate, and precise assays are described to determine BNP7787 (disodium 2,2'-dithio-bis-ethane sulfonate) and its metabolite mesna (sodium 2-mercaptoethane sulfonate) simultaneously in plasma and tissue by micro-high-performance liquid chromatography (HPLC) with dual electrochemical detection. After separation of BNP7787 and mesna
E Boven et al.
European journal of cancer (Oxford, England : 1990), 38(8), 1148-1156 (2002-05-15)
BNP7787 (2',2'-dithio-bis-ethane sulphonate sodium), a water-soluble disulphide, is chemically and mechanistically different from other sulphur-containing chemoprotective agents. Presently, BNP7787 is under investigation for its protective properties with regard to the side-effects of platinum compounds. In this study, we evaluated BNP7787
Ying-Sing Li et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 59(8), 1791-1798 (2003-05-09)
Raman, and infrared spectra of mesna and dimesna have been collected in the present spectroscopic studies. Based on the group frequencies, relative intensities and Raman depolarization measurements, some vibrational assignments have been suggested. For both mesna and dimesna, at least
Dakshine Shanmugarajah et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(10), 857-866 (2009-03-13)
BNP7787 (disodium 2,2'-dithio-bis ethane sulfonate; Tavocept) is a novel water-soluble investigational agent that is undergoing clinical development for prevention and mitigation of cisplatin-induced nephrotoxicity. BNP7787 is a disulfide that undergoes thiol-disulfide exchange reactions in vivo with physiological thiols. Mesna-disulfide heteroconjugates
M Verschraagen et al.
Journal of chromatography. B, Biomedical sciences and applications, 753(2), 293-302 (2001-05-04)
A sensitive and accurate assay was developed and validated to determine BNP7787 (dimesna), a new protector against cisplatin-induced toxicities, and its metabolite mesna in plasma and urine of patients. Both analytes were measured as mesna in deproteinized plasma or in

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