SMB00908

4-Hydroxy-4-methyl-2-oxoglutaric acid dipotassium salt

95-105% (titration)

• 동의어(들): 4-Hydroxy-4-methyl-2-oxoglutaric acid dipotassium salt, Parapyruvate
• Linear Formula: C₆H₆K₂O₆
• CAS Number: 19071-44-4
• Molecular Weight: 252.30
• UNSPSC 코드: 12352106
• NACRES: NA.25

속성

• 분석: 95-105% (titration)
• 양식: powder
• 환경친화적 대안 제품 점수: old score: 46; new score: 35; Find out more about DOZN™ Scoring
• 환경친화적 대안 제품 특성: Safer Solvents and Auxiliaries; Design for Energy Efficiency; Design for Degradation; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• 색상: white to beige
• solubility: water: soluble 10 mg/mL
• 환경친화적 대안 카테고리: Re-engineered

설명

일반 설명

Parapyruvate, also known as 4-hydroxy-4-methyl-2-oxoglutarate (HMOG), is a compound formed through the polymerization of two molecules of pyruvate via aldol condensation. It is closely related to α-ketoglutarate and is believed to act as a competitive inhibitor of the α-Ketoglutarate dehydrogenase complex (KGDHC) to form succinyl coenzyme A, impacting fibroblast senescence. A decrease in KGDHC activity is also associated with neurodegenerative disorders such as Alzheimer′s and Parkinson′s diseases. The precise mechanism of parapyruvate′s inhibition of KGDHC is complex, but it interferes with the activity of this rate-limiting enzyme in the tricarboxylic acid (TCA) cycle, ultimately affecting mitochondrial function. KGDHC is crucial for oxidative decarboxylation within the TCA cycle. Parapyruvate′s potential to inhibit KGDHC paves the way for research in cell biology and biochemistry, covering cell senescence, mitochondrial dysfunction, metabolic regulation, and aging-related diseases.

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives. This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Safer Solvents and Auxiliaries”, "Energy Efficiency", and “Design for Degradation”. Click here to view its DOZN scorecard.

애플리케이션

Parapyruvate can be used

• to study mitochondrial metabolomics
• to study age related disorders (Alzheimer′s and Parkinson′s research)

생화학적/생리학적 작용

Parapyruvate is formed via an adol condensation reaction of pyruvate

특징 및 장점

High quality compound suitable for multiple research applications

기타 정보

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안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable