I4386

Iodoacetic acid

≥98.0% (T)

• 동의어(들): 2-Iodoacetic acid
• Linear Formula: ICH₂CO₂H
• CAS Number: 64-69-7
• Molecular Weight: 185.95
• Beilstein: 1739079
• EC Number: 200-590-1
• MDL number: MFCD00002685
• UNSPSC 코드: 12352106
• PubChem Substance ID: 24896056
• NACRES: NA.77

속성

• 생물학적 소스: synthetic
• Quality Level: 200
• 분석: ≥98.0% (T)
• 양식: powder or flakes
• 색상: white to yellow
• mp: 77-79 °C (lit.)
• solubility: H₂O: soluble, clear to hazy
• 저장 온도: −20°C
• SMILES string: OC(=O)CI
• InChI: 1S/C2H3IO2/c3-1-2(4)5/h1H2,(H,4,5)
• InChI key: JDNTWHVOXJZDSN-UHFFFAOYSA-N

설명

애플리케이션

Iodoacetic acid has been used as an alkylating agent for antibody AR37, serum proteins and strawberry proteome samples extracted from different stages of ripened fruit.

Reagent for the modification of cysteine residues in proteins.

생화학적/생리학적 작용

Iodoacetic acid (IAA) blocks the thiol group of cysteine. IAA inhibits glyceraldehyde-3-phosphate dehydrogenase (G3PDH) by interacting with sulfhydryl group of the active site cysteine. IAA inhibits the progression of solid Ehrlich carcinoma. IAA is one of the iodinated disinfection byproducts in drinking water. It is cytotoxic to mammalian cells.

안전성 정보

• 픽토그램: GHS06,GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H301,H314
• 예방조치 성명서: P260 - P280 - P301 + P310 + P330 - P303 + P361 + P353 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1A
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges