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Merck
모든 사진(2)

주요 문서

95054

Supelco

Azelaic acid

analytical standard

동의어(들):

Nonanedioic acid

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About This Item

Linear Formula:
HO2C(CH2)7CO2H
CAS Number:
Molecular Weight:
188.22
Beilstein:
1101094
EC Number:
MDL number:
UNSPSC 코드:
85151701
PubChem Substance ID:
NACRES:
NA.24

Grade

analytical standard

Quality Level

vapor density

6.5 (vs air)

vapor pressure

<1 mmHg ( 20 °C)

분석

≥98.5% (GC)

유통기한

limited shelf life, expiry date on the label

기술

HPLC: suitable
gas chromatography (GC): suitable

불순물

≤0.5% water

bp

286 °C/100 mmHg (lit.)

mp

106-112 °C
109-111 °C (lit.)

응용 분야

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

형식

neat

SMILES string

OC(=O)CCCCCCCC(O)=O

InChI

1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)

InChI key

BDJRBEYXGGNYIS-UHFFFAOYSA-N

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일반 설명

Azelaic acid (heptane-l,7-dicarboxylic acid), a dicarboxylic saturated acid, is an active component of some topical anti-acne preparations. It is reportedly identified in cosmetics and pharmaceuticals. Azelaic acid is found to suppress the growth of Propionibacterium spp. and reduce keratinization.
This substance is listed on the positive list of the EU regulation 10/2011 for plastics intended to come into contact with food. Find all available reference materials for compounds listed in 10/2011 here

애플리케이션

Azelaic acid may be used as an analytical reference standard for the quantification of the analyte in the following:
  • Tobacco using gas chromatography coupled to mass spectrometry (GC-MS).
  • Topical preparations using reversed-phase liquid chromatographic (LC) with UV-Vis detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

410.0 °F - closed cup

Flash Point (°C)

210 °C - closed cup


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Simultaneous determination of azelaic and benzoic acids in topical preparations by liquid chromatography
Mansour MA and Ibrahiem MM
Chromatographia, 55(7-8), 435-437 (2002)
James Q Del Rosso
Cutis, 77(2 Suppl), 22-24 (2006-03-29)
Topical azelaic acid (AzA) is approved for the treatment of acne vulgaris and inflammatory (papulopustular) rosacea. Because of diverse mechanisms of action that correlate with potential therapeutic benefit, AzA has been used to treat several common dermatoses including acne vulgaris
Boni Elewski et al.
Cutis, 77(2 Suppl), 12-16 (2006-03-29)
Azelaic acid (AzA) initially was released in a 20% cream formulation, which has been shown to be effective in the treatment of mild to moderate rosacea. Recently, a 15% gel formulation was developed that vastly improved the delivery of AzA
James E Frampton et al.
American journal of clinical dermatology, 5(1), 57-64 (2004-02-26)
Azelaic acid is a naturally occurring, straight-chain dicarboxylic acid which is effective in the treatment of rosacea, presumably on account of its anti-inflammatory properties. In randomized, double-blind, multicenter studies involving patients with moderate papulopustular facial rosacea, twice-daily topical application of
P S Mackrides et al.
American family physician, 54(8), 2457-2459 (1996-12-01)
Azelaic acid is another option for the topical treatment of mild to moderate inflammatory acne vulgaris. It offers effectiveness similar to that of other agents without the systemic side effects of oral antibiotics or the allergic sensitization of topical benzoyl

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