21186

Calcium ionophore III

Selectophore^™, function tested

• 동의어(들): Calcium Ionophore A23187, Antibiotic A 23187, Calimycin
• 실험식(Hill 표기법): C₂₉H₃₇N₃O₆
• CAS Number: 52665-69-7
• Molecular Weight: 523.62
• Beilstein: 1096801
• EC Number: 258-084-1
• MDL number: MFCD00151202
• UNSPSC 코드: 26111700
• PubChem Substance ID: 329752113
• NACRES: NB.61

속성

• 설명: for ion-selective electrodes
• Quality Level: 200
• 제품 라인: Selectophore^™
• 양식: solid
• 품질: function tested
• 항생제 활성 스펙트럼: Gram-positive bacteria; fungi
• 동작 모드: cell membrane | interferes
• 저장 온도: 2-8°C
• SMILES string: [H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c5ccc[nH]5
• InChI: 1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1
• InChI key: HIYAVKIYRIFSCZ-CYEMHPAKSA-N

설명

일반 설명

Calcium ionophore III (Calimycin;CA) is a divalent cation ionophore. It has ability to transport Ca²⁺ ions across membranes along a concentration gradient.

Visit our Sensor Applications portal to learn more.

애플리케이션

CA was used in elucidating the mechanisms underlying the positive and inotropic and chronotropic ability of CA on isolated superfused guinea pig atria. It may also be used to stimulate and measure the erythrocyte Ca²⁺ dependent K⁺ channels as the K⁺ efflux.

Calcium ionophore III may be used in ionophore-based calcium selective conductometric microsensors for the detection of calcium ions in aqueous solutions. In NIH3T3 and rat1-fibroblast cell cultures, calcium ionophore III along with thapsigargin has been reported to increase the hepatic clock gene Per1 expression in the initial period of treatment.

Ionophore highly selective for Ca²⁺. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

기타 정보

Preparation of an optical chemical sensor for Ca²⁺ and Mg²⁺

법적 정보

Selectophore is a trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves