MABN352

Anti-delta-type Opioid Receptor, clone 4E6.2 Antibody

clone 4E6.2, from mouse

• 동의어(들): Delta-type opioid receptor, D-OR-1, DOR-1
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified antibody
• 항체 생산 유형: primary antibodies
• 클론: 4E6.2, monoclonal
• 종 반응성: human, mouse
• 기술: immunohistochemistry: suitable (paraffin); western blot: suitable
• 동형: IgG2bκ
• NCBI 수납 번호: NP_000902
• UniProt 수납 번호: P41143
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... OPRD1(4985)

설명

일반 설명

Delta-type Opioid Receptor (D-OR-1), also known as DOR-1, and encoded by the gene name OPRD1/ OPRD, is a G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Binding of Delta-type Opioid Receptor with ligands causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Delta-type Opioid Receptor signaling has been shown to lead to the inhibition of adenylate cyclase activity. Recent studies have also demonstrated that Delta-type Opioid Receptor inhibits the neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Delta-type Opioid Receptor also may play a role in the perception of pain and in opiate-mediated analgesia. Additionally, it may play a role in developing analgesic tolerance to morphine, and it may form homooligomers. Delta-type Opioid Receptor interacts with GPRASP1. Delta-type Opioid Receptor is detected in oocytes (at protein level), and in brain cortex, hypothalamus, hippocampus and olfactory bulb.

면역원

Epitope: C-terminus

GST-tagged recombinant protein corresponding to the C-terminus of human delta-type Opioid Receptor.

애플리케이션

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected delta-type Opioid Receptor in human cerebral cortex, human uterus, and human thalamus tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

This Anti-delta-type Opioid Receptor antibody is validated for use in WB, IH(P) for the detection of delta-type Opioid Receptor.

품질

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected delta-type Opioid Receptor in 10 µg of mouse brain tissue lysate.

표적 설명

~65 kDa observed. The calculated molecular weight of this protein is 40 kDa, but can be observed at ~65 kDa due to high glycosylation.

물리적 형태

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to lot specific datasheet.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable