추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
purified antibody
항체 생산 유형
primary antibodies
클론
6C1.2, monoclonal
종 반응성
mouse
기술
western blot: suitable
입력
sample type: mouse embryonic stem cell(s)
동형
IgG2aκ
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
mouse ... Dppa2(73703)
일반 설명
DPPA-2 (developmental pluripotency associated-2) is a novel Oct-4-related protein that is localized to the nucleus of mouse fetal germ cells. DPPA-2 has binding sites for both POU and Sox-2 protein domains and is expressed primarily in the developing germ line following gastrulation. These associations suggest that this protein participates in a very strong supportive role in maintaining cell pluripotentiality. In addition to its role as a pluripotency marker, more recent research using cancer cells suggests that DPPA-2 may also act as an embryo-cancer antigen—pointing to the presence of abnormal cell growth and the formation of cancerous cells.
특이성
Reactivity with other species has not been tested.
This monoclonal antibody recognizes the mouse DPPA-2 protein.
면역원
Full length recombinant mouse DPPA-2 protein.
애플리케이션
Research Category
Stem Cell Research
Stem Cell Research
Research Sub Category
Pluripotent & Early Differentiation
Pluripotent & Early Differentiation
This Anti-DPPA-2 Antibody, clone 6C1.2 is validated for use in WB for the detection of DPPA-2.
품질
(Based upon representative data from a previous lot).
Western Blotting: Recommended working concentration is 2 µg/mL.
Western Blotting: Recommended working concentration is 2 µg/mL.
표적 설명
~34 kDa
물리적 형태
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4) and
150 mM NaCl with 0.05% sodium azide.
150 mM NaCl with 0.05% sodium azide.
저장 및 안정성
Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Mélanie Eckersley-Maslin et al.
Genes & development, 33(3-4), 194-208 (2019-01-30)
The molecular regulation of zygotic genome activation (ZGA) in mammals remains an exciting area of research. Primed mouse embryonic stem cells contain a rare subset of "2C-like" cells that are epigenetically and transcriptionally similar to the two-cell embryo and thus
Oana Kubinyecz et al.
Development (Cambridge, England), 148(24) (2021-12-22)
Zygotic genome activation (ZGA) represents the initiation of transcription following fertilisation. Despite its importance, we know little of the molecular events that initiate mammalian ZGA in vivo. Recent in vitro studies in mouse embryonic stem cells have revealed developmental pluripotency
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