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Merck
모든 사진(1)

주요 문서

AB2255

Sigma-Aldrich

Anti-GABA B Receptor R2 Antibody

serum, from guinea pig

동의어(들):

G protein-coupled receptor 51, G-protein coupled receptor 51, GABA-B receptor 2, gamma-aminobutyric acid (GABA) B receptor, 2, gamma-aminobutyric acid B receptor, 2, GABA-B-R2, GABA(B)R2

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모든 사진(1)

About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41

생물학적 소스

guinea pig

Quality Level

100

항체 형태

serum

항체 생산 유형

primary antibodies

클론

polyclonal

종 반응성

rhesus macaque, rat

종 반응성(상동성에 의해 예측)

canine (based on 100% sequence homology), bovine (based on 100% sequence homology), human (based on 100% sequence homology), horse (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), mouse (based on 100% sequence homology)

기술

immunohistochemistry: suitable
western blot: suitable

NCBI 수납 번호

NP_113990

UniProt 수납 번호

O88871

배송 상태

wet ice

타겟 번역 후 변형

unmodified

유전자 정보

human ... GABBR2(9568)

일반 설명

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.

특이성

This antibody recognizes the C-terminus of rat GABA-B-R2.

면역원

Bovine thyroglobulin-conjugated linear peptide at the C-terminus of rat GABA-B-R2.

애플리케이션

Anti-GABA B Receptor R2 Antibody is an antibody against GABA B Receptor R2 for use in IH & WB.

품질

Evaluated by Immunohistochemistry in Purkinje cells in rat mid-brain region.

Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected GABA-B-R2 in Purkinje cells in rat mid-brain region.

표적 설명

Although a band is observed around the calculated molecular weight of 105 kDa, Western Blotting is not a recommened application for this antibody because the band is weak in comparison to other non-specific bands present.

결합

Replaces: AB5394

분석 메모

Control
Purkinje cells in rat mid-brain region

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

Yupeng Miao et al.
Nature communications, 12(1), 4518-4518 (2021-07-28)
Multiplexed optical imaging provides holistic visualization on a vast number of molecular targets, which has become increasingly essential for understanding complex biological processes and interactions. Vibrational microscopy has great potential owing to the sharp linewidth of vibrational spectra. In 2017
Francisco Ciruela et al.
The European journal of neuroscience, 32(8), 1265-1277 (2010-09-18)
The stimulation of inhibitory neurotransmitter receptors, such as γ-aminobutyric acid type B (GABA(B) ) receptors, activates G protein-gated inwardly-rectifying K(+) (GIRK) channels, which influence membrane excitability. There is now evidence suggesting that G protein-coupled receptors and G protein-gated inwardly-rectifying K(+)
Chuanyin Hu et al.
Molecular medicine reports, 15(2), 975-980 (2016-12-31)
Chemotherapeutic drugs commonly induce peripheral neuropathic pain, which limit their clinic use. In the present study, the effect of fucoidan on the development of vincristine‑induced neuropathic pain was evaluated and the underlying mechanism was examined. A neuropathy model was established

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