8.52126

Fmoc-Cys(Trt)-OPfp

Novabiochem^®

• 동의어(들): Fmoc-Cys(Trt)-OPfp, N-α-Fmoc-S-trityl-L-cysteine pentafluorophenyl ester
• 실험식(Hill 표기법): C₄₃H₃₀F₅NO₄S
• CAS Number: 115520-21-3
• Molecular Weight: 751.76
• MDL number: MFCD00065639
• UNSPSC 코드: 12352209
• NACRES: NA.22

속성

• Quality Level: 200
• 제품 라인: Novabiochem^®
• 분석: ≥97.0% (HPLC)
• 양식: powder
• 반응 적합성: reaction type: Fmoc solid-phase peptide synthesis
• 제조업체/상표: Novabiochem^®
• 응용 분야: peptide synthesis
• 작용기: thiol
• 저장 온도: 15-25°C
• SMILES string: Fc1c(c(c(c(c1F)F)OC(=O)[C@@H](NC(=O)OCC5c6c(cccc6)c7c5cccc7)CSC(c4ccccc4)(c3ccccc3)c2ccccc2)F)F
• InChI: 1S/C43H30F5NO4S/c44-35-36(45)38(47)40(39(48)37(35)46)53-41(50)34(49-42(51)52-24-33-31-22-12-10-20-29(31)30-21-11-13-23-32(30)33)25-54-43(26-14-4-1-5-15-26,27-16-6-2-7-17-27)28-18-8-3-9-19-28/h1-23,33-34H,24-25H2,(H,49,51)/t34-/m0/s1
• InChI key: FDAUCYDVXIPBDR-UMSFTDKQSA-N

설명

일반 설명

Pre-formed pentafluorophenyl ester for coupling of cysteine residues for Fmoc SPPS without enantiomerization ^[1,2]. Enables use of bromophenol blue monitoring of amide bond formation.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Cysteine-Containing Peptides

Literature references

^[1] T. Kaiser, et al. (1996) Tetrahedron Lett., 37, 1187.
^[2] Y. X. Han, et al. (1997) J. Org. Chem., 62, 4307

결합

Replaces: 04-12-1504

분석 메모

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in chloroform): +14.0 - +17.0 °
Purity (TLC (0004)): <3% DCU
Assay (HPLC, area%): ≥ 97.0% (a/a)
Solubility (0,5 mmole in 3 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.

법적 정보

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315
• 예방조치 성명서: P264 - P280 - P302 + P352 - P332 + P313 - P362 + P364
• Hazard Classifications: Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable