8.51095

PyOxim

≥99.0% (HPLC), for peptide synthesis, Novabiochem^®

• 동의어(들): PyOxim, 1-Cyano-2-ethoxy-2-oxoethylideneaminooxy-tris-pyrrolidino-phosphonium hexafluorophosphate
• 실험식(Hill 표기법): C₁₇H₂₉F₆N₅O₃P₂
• CAS Number: 153433-21-7
• Molecular Weight: 527.38
• MDL number: MFCD18643381
• UNSPSC 코드: 12352126
• NACRES: NA.22

속성

• 제품명: PyOxim, Novabiochem^®
• Quality Level: 300
• 제품 라인: Novabiochem^®
• 분석: ≥99.0% (HPLC)
• 양식: powder
• 반응 적합성: reaction type: Coupling Reactions
• 제조업체/상표: Novabiochem^®
• 응용 분야: peptide synthesis
• 저장 온도: 15-25°C
• SMILES string: F[P-](F)(F)(F)(F)F.[P](=[N+]3CCCC3)(N2CCCC2)(N1CCCC1)O\N=C(\C(=O)OCC)/C#N
• InChI: 1S/C17H29N5O3P.F6P/c1-2-24-17(23)16(15-18)19-25-26(20-9-3-4-10-20,21-11-5-6-12-21)22-13-7-8-14-22;1-7(2,3,4,5)6/h2-14H2,1H3;/q+1;-1/b19-16+;
• InChI key: RDWDVLFMPFUBDV-PXMDEAMVSA-N

설명

일반 설명

PyOxim ^[1] is a novel reagent which mediates coupling reactions with efficiencies superior to HATU and PyBOP and comparable to COMU. It is has excellent solubility in DMF and is stable in solution under an inert atmosphere for two days. Unlike HATU and HBTU, it cannot cause chain terminating side reactions and is, therefore, ideal for the synthesis of cyclic peptides. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents.


Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] R. Subiros-Funosas, et al. (2010) Org. Biomol. Chem., 8, 3665.

특징 및 장점

• Mediates coupling with superior efficiency to PyBOP, TBTU, and HCTU
• Mediates coupling with low racemization or epimerization
• Ideal for fragment condensation and synthesis of cyclic peptides as the reagent cannot cause guanidinylation
• Excellent solubility in DMF and NMP

분석 메모

Colour (visual): white to off white
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 %
Solubility (1 mmole in 2 ml DMF): clearly soluble

법적 정보

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable