676777

(±)-Verapamil, Hydrochloride

A papaverine derivative that blocks Ca²⁺ channels (principally the L-type) in smooth and cardiac muscle cells.

• 동의어(들): (±)-Verapamil, Hydrochloride, L-Type Calcium Channel Blocker V
• 실험식(Hill 표기법): C₂₇H₃₈N₂O₄ · xHCl
• CAS Number: 152-11-4
• Molecular Weight: 454.60 (free base basis)
• MDL number: MFCD00055208
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 설명: Merck USA index - 14, 9950
• 분석: ≥99% (perchloric acid titration)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: white
• solubility: methanol: 50 mg/mL; water: 70 mg/mL; ethanol: soluble
• 배송 상태: ambient
• 저장 온도: 10-30°C
• SMILES string: [Cl-].[N+H](CCCC(C(C)C)(c2cc(c(cc2)OC)OC)C#N)(CCc1cc(c(cc1)OC)OC)C
• InChI: 1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
• InChI key: DOQPXTMNIUCOSY-UHFFFAOYSA-N

설명

일반 설명

A derivative of papaverine that blocks Ca²⁺ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Inhibits the entry of Ca²⁺ through voltage-dependent Ca²⁺ channels in cell membranes. Blocks both activated and inactivated Ca²⁺ channels. An adrenergic antagonist. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.

A papaverine derivative that blocks Ca²⁺ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Known to reduce the renal clearance of digoxin. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.

생화학적/생리학적 작용

Cell permeable: no

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Toxic (F)

기타 정보

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Lonsberry, B.B., et al. 1994. Pharmacology 49, 23.
Shchepotin, I.B., et al. 1994. Anticancer Res.14, 1027.
Janis, R., et al. 1987. Adv. Drug Res.16, 309.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS06,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H301,H411
• 예방조치 성명서: P264 - P273 - P301 + P310 - P391 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable