551476

Q-VD-OPh, Non-O-methylated

≥90% (HPLC), liquid, Caspase inhibitor, Calbiochem^®

• 동의어(들): InSolution Q-VD-OPh, Non-O-methylated, N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
• 실험식(Hill 표기법): C₂₆H₂₅F₂N₃O₆
• Molecular Weight: 513.49
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 제품명: Q-VD-OPh, Non-O-methylated, InSolution, ≥90%, irreversible broad-spectrum inhibitor of caspases
• Quality Level: 100
• 분석: ≥90% (HPLC)
• 양식: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 배송 상태: wet ice
• 저장 온도: −20°C

설명

일반 설명

A cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC₅₀ = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
caspase-1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively

포장

Packaged under inert gas

경고

Toxicity: Irritant (B)

서열

Q-Val-Asp-CH₂-OPh

물리적 형태

Supplied as a 10 mM (1 mg/195 µl) solution in DMSO.

재구성

Following initial thaw, aliquot and freeze (-20°C).

기타 정보

Braun, J.S., et al. 2007. Exp. Neurol.206, 183.
Caserta, T.M., et al. 2003. Apoptosis8, 345.
Rebbaa, A., et al. 2003. Oncogene22, 2805.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Flash Point (°C): 87 °C - closed cup - (Dimethylsulfoxide)