5.09228

Y-27632

≥95% (HPLC), liquid, Rho kinase inhibitor, Calbiochem

• 동의어(들): InSolution Y-27632, Sterile-Filtered, Cell Culture-Tested
• 실험식(Hill 표기법): C₁₄H₂₁N₃O · 2HCl
• CAS Number: 146986-50-7
• Molecular Weight: 320.26
• MDL number: MFCD18829832
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 제품명: Y-27632, InSolution, ≥95%, 10 mM aqueous solution, Sterile-Filtered, inhibitor of Rho-associated protein kinases
• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• 저장 온도: −20°C
• SMILES string: N[C@@H](C1CCC(CC1)C(=O)Nc2ccncc2)C
• InChI: 1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11?,12?/m1/s1
• InChI key: IYOZTVGMEWJPKR-VOMCLLRMSA-N

설명

일반 설명

A 10 mM (2 mg/591 µL) sterile-filtered solution of Y-27632 in H₂O.

Ready to use, cell culture-tested, suitable for stem cell applications. Acts as a highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (K_i = 140 nM for p160ROCK). Also shown to improve survival of human stem cells especially during cell culture passage and manipulation.

애플리케이션

InSolution Y-27632, Sterile-Filtered, Cell Culture-Tested, CAS 146986-50-7, is a 10 mM sterile-filtered solution of Y-27632 in H₂O. Acts as an inhibitor of Rho kinases (Ki = 140 nM for p160ROCK).

생화학적/생리학적 작용

Primary Target
ROCK

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

물리적 형태

A 10 mM (2 mg/591 µL) sterile-filtered solution of Y-27632 (Cat. No. 688000) in H₂O.

재구성

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

기타 정보

Li X. et al, et. Al., 2009. Human Reproduction, 24, 580.
Chitaley, K., et al. 2001. Nat. Med.7, 119.
Davies, S.P., et al. 2000. Biochem. J.351, 95.
Narumiya, S., et al. 2000. Methods Enzymol.325, 273.
Hirose, M., et al. 1999. J. Cell Biol.141, 1625.
Maekawa, M., et al. 1999. Science.285, 895.
Uehata, M., et al. 1997. Nature.389, 990.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable