491207

Novobiocin sodium salt

≥90% (HPLC), powder, DNA gyrase inhibitor, Calbiochem^®

• 동의어(들): Novobiocin, Sodium Salt
• 실험식(Hill 표기법): C₃₁H₃₅N₂O₁₁ · Na
• CAS Number: 1476-53-5
• Molecular Weight: 634.61
• MDL number: MFCD30207859
• UNSPSC 코드: 51286504

속성

• 제품명: Novobiocin, Sodium Salt,
• 분석: ≥90% (HPLC)
• 양식: powder
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white to yellow
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: [Na+].N([C-]2C(=O)Oc3c(ccc(c3C)OC4OC(C(C(C4O)OC(=O)N)OC)(C)C)C2=O)C(=O)c1cc(c(cc1)O)CC=C(C)C
• InChI: 1S/C31H35N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34,36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q-1;+1
• InChI key: AXOUUAINTJNFRS-UHFFFAOYSA-N

설명

일반 설명

A DNA gyrase inhibitor that can be used for the production of positively supercoiled plasma DNA. Targets the nucleotide-binding site of gyrase B. Exhibits antibacterial properties. Inhibits retrovirus RNA-dependent DNA polymerases. Inhibits LPS-induced production of pro-inflammatory cytokines. Reported to act as a potent inhibitor of ADP ribosylation. Also inhibits protein synthesis and alters the phosphorylation state of several cytosolic proteins.

DNA gyrase inhibitor used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases. Also a potent inhibitor of ADP ribosylation eliminates the wild-type pMG110 plasmid from E. coli.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
retrovirus RNA-dependent DNA polymerases

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Harmful (C)

재구성

Following reconstitution, refrigerate (4°C). Stock solutions are stable for 3 months at 4°C.

기타 정보

Marcu, M.G., et al. 2000. J. Natl. Cancer Inst.92, 242.
Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp.42, 1911.
Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586.
Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999.
Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329.
Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H317,H319
• 예방조치 성명서: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable