345670

Galanthamine, Hydrobromide

A competitive and reversible inhibitor of acetylcholinesterase.

• 동의어(들): Galanthamine, Hydrobromide, Nivalin, HBr
• 실험식(Hill 표기법): C₁₇H₂₁NO₃ · xHBr
• CAS Number: 69353-21-5
• Molecular Weight: 287.35 (free base basis)
• MDL number: MFCD05734759
• UNSPSC 코드: 12352116
• NACRES: NA.77

속성

• Quality Level: 100
• 설명: Merck USA index - 14, 4340
• 분석: ≥95% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated
• 색상: white
• solubility: ethanol: 1 mg/mL; water: 1 mg/mL; DMSO: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: [Br-].[N+H]1(CC[C@@]32[C@@H](Oc4c3c(ccc4OC)C1)C[C@H](C=C2)O)C
• InChI: 1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1
• InChI key: QORVDGQLPPAFRS-XPSHAMGMSA-N

설명

일반 설명

A competitive and reversible inhibitor of acetylcholinesterase. Antimyasthenic agent. Can partially reverse the effects of scopolamine-induced amnesia in rats. Reported to improve learning and short-term memory in animal models.

Cholinesterase antagonist. Antimyasthenic agent. Can partially reverse the effects of scopolamine-induced amnesia in rats.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Acetylcholinesterase

Product competes with ATP.

Reversible: yes

경고

Toxicity: Toxic (F)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Pilger, C., et al. 2001. J. Mol. Graph. Model19, 288.
Iliev, A., et al. 1999. Methods Find. Exp. Clin. Pharmacol. 21, 297.
Southan, G.J., et al. 1996. Br. J. Pharmacol.117, 619.
Mutafova-Yambolieva, V.N., et al. 1993. Gen. Pharmacol. 24, 1253.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable