324694

Emodin

A cell-permeable, reversible, substrate competitive and potent p56^lck tyrosine kinase inhibitor (IC₅₀ = 18.5 µM).

• 동의어(들): Emodin, 6-Methyl-1,3,8-trihydroxyanthraquinone
• 실험식(Hill 표기법): C₁₅H₁₀O₅
• CAS Number: 518-82-1
• Molecular Weight: 270.24
• MDL number: MFCD00001207
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 설명: Merck USA index - 14, 3561
• 분석: ≥90% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: orange
• solubility: DMSO: 1 mg/mL; aqueous base: soluble; ethanol: soluble
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: Oc1c2c(cc(c1)O)C(=O)c3c(c(cc(c3)C)O)C2=O
• InChI: 1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
• InChI key: RHMXXJGYXNZAPX-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable, reversible, substrate competitive and potent p56^lck tyrosine kinase inhibitor (IC₅₀ = 18.5 µM). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC₅₀ = 14.8 µM) without affecting normal human bronchial epithelial cells, even at a concentration of 370 mM. Reported to act as an inhibitor of Tau aggregation and aid in the disassembly of PHF in vitro and in vivo.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
p56^lck tyrosine kinase

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 18.5 µM against p56lck tyrosine kinase

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous alkali; reconstitute just prior to use.

기타 정보

Pickhardt, M., et al. 2004. J. Biol. Chem.280, 3628.
Zhang, L., and Hung. M.C. 1996. Oncogene 12, 571.
Chan, T.C., et al. 1993. Biochem. Biophys. Res. Commun. 193, 1152.
Jayasuriya, H., et al. 1992. J. Nat. Prod.55, 696.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable