124008

Akt Inhibitor II

The Akt Inhibitor II controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): Akt Inhibitor II, SH-5
• 실험식(Hill 표기법): C₂₉H₅₉O₁₀P
• Molecular Weight: 598.75
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (NMR)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: white
• solubility: DMSO: 10 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

A cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and selected downstream substrates without affecting the phosphorylation of PDK-1 and other downstream kinases. Decreases phosphorylation of Akt without affecting the total Akt level. Reported to be a potent inducer of apoptosis and to selectively kill a variety of cancer cell lines expressing high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit ~50% of PKA activity.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
Akt

Product does not compete with ATP.

Reversible: yes

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Gills, J.J., et al. 2007. J. Biol. Chem.in press.
Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable