1.04352

L-Histidine

EMPROVE^® EXPERT, Ph. Eur., ChP, JP, USP

• 동의어(들): His, (S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773
• 실험식(Hill 표기법): C₆H₉N₃O₂
• CAS Number: 71-00-1
• Molecular Weight: 155.15
• Beilstein: 84088
• MDL number: MFCD00064315
• UNSPSC 코드: 12352209
• EC 인덱스 번호: 200-745-3

속성

• Agency: ChP; JP; Ph. Eur.; USP
• Quality Level: 500
• 제품 라인: EMPROVE^® EXPERT
• 양식: solid
• 기술: API processing | cocrystal formation: suitable
• pH: 7.7 (20 °C, 10 g/L in H₂O)
• mp: 282 °C (dec.) (lit.)
• 응용 분야: liquid formulation; parenterals; pharma/biopharma processes; pharmaceutical
• 저장 온도: 2-30°C
• SMILES string: N[C@@H](Cc1c[nH]cn1)C(O)=O
• InChI: 1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
• InChI key: HNDVDQJCIGZPNO-YFKPBYRVSA-N

설명

일반 설명

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

애플리케이션

Histidine is used in biopharma manufacturing as a buffer in formulation. It is often used together with histidine monohydrochloride to prepare histidine buffer with the desired pH value.
Due to its low microbial and endotoxin limits, L-Histidine Emprove^® Expert is especially suitable for high-risk applications.

생화학적/생리학적 작용

Precursor of histamine by action of histidine decarboxylase.

법적 정보

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable