100065
2-APB
≥97% (titration), crystalline solid, Ins(1,4,5)P3-induced Ca2+ release inhibitor, Calbiochem®
동의어(들):
2-APB, 2-Aminoethoxydiphenylborate, (2-Aminoethoxy)diphenylborane
로그인조직 및 계약 가격 보기
모든 사진(1)
About This Item
실험식(Hill 표기법):
C14H16BNO
CAS Number:
Molecular Weight:
225.09
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
제품명
2-APB, A cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release.
Quality Level
설명
RTECS - ED6150000
분석
≥97% (titration)
양식
crystalline solid
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
desiccated (hygroscopic)
색상
white
solubility
DMSO: 20 mg/mL
95% ethanol: 25 mg/mL
배송 상태
ambient
저장 온도
2-8°C
SMILES string
B(OCCN)(c2ccccc2)c1ccccc1
InChI
1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
InChI key
BLZVCIGGICSWIG-UHFFFAOYSA-N
일반 설명
A cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release. Inhibits Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations (IC50 = 42 µM) without affecting [3H]-Ins(1,4,5)P3 binding to its receptor. In liver cells, 2-APB inhibits store-operated Ca2+ channels through a mechanism which may involve its binding to either the channel protein or an associated regulatory protein. Has no effect on the Ca2+ release from the ryanodine-sensitive Ca2+ store prepared from rat leg skeletal muscle and heart.
생화학적/생리학적 작용
Cell permeable: yes
Primary Target
Ins(1,4,5)P3-induced Ca2+ release
Ins(1,4,5)P3-induced Ca2+ release
Product does not compete with ATP.
Reversible: no
Target IC50: 42 µM against Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations
포장
Packaged under inert gas
경고
Toxicity: Standard Handling (A)
재구성
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
기타 정보
Brooke, R. T., et al. 2004. Lab. Invest.84, 29.
Gregory, R.B., et al. 2001. Biochem. J.354, 285.
Ma, H.T., et al. 2001. J. Biol. Chem.276, 18888.
Ascher-Landsberg, S., et al. 1999. Biochem. Biophys. Res. Commun.264, 979.
Maruyama, T., et al. 1997. J. Biochem.122, 498.
Gregory, R.B., et al. 2001. Biochem. J.354, 285.
Ma, H.T., et al. 2001. J. Biol. Chem.276, 18888.
Ascher-Landsberg, S., et al. 1999. Biochem. Biophys. Res. Commun.264, 979.
Maruyama, T., et al. 1997. J. Biochem.122, 498.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
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